4BVA
Crystal structure of the NADPH-T3 form of mouse Mu-crystallin.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006839 | biological_process | mitochondrial transport |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0042562 | molecular_function | hormone binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0047125 | molecular_function | delta1-piperideine-2-carboxylate reductase activity |
| A | 0047127 | molecular_function | thiomorpholine-carboxylate dehydrogenase activity |
| A | 0050241 | molecular_function | pyrroline-2-carboxylate reductase activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070324 | molecular_function | thyroid hormone binding |
| A | 0070327 | biological_process | thyroid hormone transport |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0003714 | molecular_function | transcription corepressor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006839 | biological_process | mitochondrial transport |
| B | 0007605 | biological_process | sensory perception of sound |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042403 | biological_process | thyroid hormone metabolic process |
| B | 0042562 | molecular_function | hormone binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0047125 | molecular_function | delta1-piperideine-2-carboxylate reductase activity |
| B | 0047127 | molecular_function | thiomorpholine-carboxylate dehydrogenase activity |
| B | 0050241 | molecular_function | pyrroline-2-carboxylate reductase activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070324 | molecular_function | thyroid hormone binding |
| B | 0070327 | biological_process | thyroid hormone transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NDP A 1313 |
| Chain | Residue |
| A | HIS91 |
| A | ASN167 |
| A | ARG168 |
| A | THR169 |
| A | ASN172 |
| A | VAL203 |
| A | THR204 |
| A | MET205 |
| A | ALA206 |
| A | VAL225 |
| A | GLY226 |
| A | THR115 |
| A | SER228 |
| A | SER291 |
| A | LEU292 |
| A | GLY293 |
| A | T31314 |
| A | HOH2127 |
| A | HOH2143 |
| A | HOH2144 |
| A | HOH2146 |
| A | HOH2159 |
| A | ARG118 |
| A | HOH2181 |
| A | HOH2201 |
| A | HOH2259 |
| A | HOH2260 |
| A | HOH2261 |
| A | HOH2262 |
| A | THR119 |
| A | GLY142 |
| A | ALA143 |
| A | GLY144 |
| A | VAL145 |
| A | GLN146 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP B 1313 |
| Chain | Residue |
| B | THR115 |
| B | ARG118 |
| B | THR119 |
| B | GLY142 |
| B | ALA143 |
| B | GLY144 |
| B | VAL145 |
| B | GLN146 |
| B | ASN167 |
| B | ARG168 |
| B | THR169 |
| B | ASN172 |
| B | VAL203 |
| B | THR204 |
| B | MET205 |
| B | ALA206 |
| B | VAL225 |
| B | GLY226 |
| B | SER228 |
| B | SER291 |
| B | LEU292 |
| B | GLY293 |
| B | T31314 |
| B | HOH2113 |
| B | HOH2136 |
| B | HOH2153 |
| B | HOH2155 |
| B | HOH2169 |
| B | HOH2177 |
| B | HOH2202 |
| B | HOH2268 |
| B | HOH2269 |
| B | HOH2270 |
| B | HOH2271 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE T3 B 1314 |
| Chain | Residue |
| B | ARG47 |
| B | PHE58 |
| B | GLY60 |
| B | PHE79 |
| B | SER228 |
| B | ARG229 |
| B | PRO230 |
| B | TRP232 |
| B | GLU256 |
| B | NDP1313 |
| B | HOH2074 |
| B | HOH2076 |
| B | HOH2077 |
| B | HOH2262 |
| B | HOH2272 |
| B | HOH2273 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE T3 A 1314 |
| Chain | Residue |
| A | ARG47 |
| A | PHE58 |
| A | PHE79 |
| A | SER228 |
| A | ARG229 |
| A | GLU256 |
| A | NDP1313 |
| A | HOH2063 |
| A | HOH2064 |
| A | HOH2126 |
| A | HOH2245 |
| A | HOH2264 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 1315 |
| Chain | Residue |
| A | ALA220 |
| A | CYS283 |
| A | LYS285 |
| A | THR287 |
| A | LEU130 |
| A | GLY219 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 1315 |
| Chain | Residue |
| B | LEU130 |
| B | GLY219 |
| B | ALA220 |
| B | CYS283 |
| B | LYS285 |
| B | THR287 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24467707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BVA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24467707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BV9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24467707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BV9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BVA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4BV9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4BVA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4BV9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BVA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
