4BV9
Crystal structure of the NADPH form of mouse Mu-crystallin.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006839 | biological_process | mitochondrial transport |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0042562 | molecular_function | hormone binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0047127 | molecular_function | thiomorpholine-carboxylate dehydrogenase activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070324 | molecular_function | thyroid hormone binding |
| A | 0070327 | biological_process | thyroid hormone transport |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0003714 | molecular_function | transcription corepressor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006839 | biological_process | mitochondrial transport |
| B | 0007605 | biological_process | sensory perception of sound |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042403 | biological_process | thyroid hormone metabolic process |
| B | 0042562 | molecular_function | hormone binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0047127 | molecular_function | thiomorpholine-carboxylate dehydrogenase activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070324 | molecular_function | thyroid hormone binding |
| B | 0070327 | biological_process | thyroid hormone transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NDP B 1312 |
| Chain | Residue |
| B | SER90 |
| B | ASN167 |
| B | ARG168 |
| B | THR169 |
| B | ASN172 |
| B | VAL203 |
| B | THR204 |
| B | MET205 |
| B | VAL225 |
| B | GLY226 |
| B | SER291 |
| B | HIS91 |
| B | LEU292 |
| B | GLY293 |
| B | HOH2043 |
| B | HOH2044 |
| B | HOH2062 |
| B | HOH2073 |
| B | HOH2112 |
| B | THR115 |
| B | ARG118 |
| B | THR119 |
| B | ALA143 |
| B | GLY144 |
| B | VAL145 |
| B | GLN146 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NDP A 1312 |
| Chain | Residue |
| A | SER90 |
| A | HIS91 |
| A | ARG118 |
| A | THR119 |
| A | GLY142 |
| A | ALA143 |
| A | GLY144 |
| A | VAL145 |
| A | GLN146 |
| A | ASN167 |
| A | ARG168 |
| A | THR169 |
| A | ASN172 |
| A | VAL203 |
| A | THR204 |
| A | MET205 |
| A | ALA206 |
| A | VAL225 |
| A | GLY226 |
| A | SER291 |
| A | LEU292 |
| A | GLY293 |
| A | PYR1313 |
| A | HOH2047 |
| A | HOH2048 |
| A | HOH2065 |
| A | HOH2075 |
| A | HOH2091 |
| A | HOH2119 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EPE B 1313 |
| Chain | Residue |
| A | ASN33 |
| A | GLY40 |
| A | GLY41 |
| A | ALA67 |
| B | LYS54 |
| B | SER189 |
| B | VAL190 |
| B | GLN191 |
| B | TRP215 |
| B | HOH2084 |
| B | HOH2113 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1314 |
| Chain | Residue |
| B | ASP70 |
| B | PRO100 |
| B | LYS303 |
| B | HOH2040 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR A 1313 |
| Chain | Residue |
| A | ARG47 |
| A | MET62 |
| A | LYS75 |
| A | THR115 |
| A | ARG118 |
| A | LEU292 |
| A | GLY293 |
| A | NDP1312 |
| A | HOH2099 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY142 | |
| A | ASN167 | |
| A | ARG168 | |
| B | GLY142 | |
| B | ASN167 | |
| B | ARG168 |
