4BPT

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0004505	molecular_function	phenylalanine 4-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006559	biological_process	L-phenylalanine catabolic process
A	0006571	biological_process	L-tyrosine biosynthetic process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B	0004497	molecular_function	monooxygenase activity
B	0004505	molecular_function	phenylalanine 4-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0006559	biological_process	L-phenylalanine catabolic process
B	0006571	biological_process	L-tyrosine biosynthetic process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
C	0004497	molecular_function	monooxygenase activity
C	0004505	molecular_function	phenylalanine 4-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0006559	biological_process	L-phenylalanine catabolic process
C	0006571	biological_process	L-tyrosine biosynthetic process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
D	0004497	molecular_function	monooxygenase activity
D	0004505	molecular_function	phenylalanine 4-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0006559	biological_process	L-phenylalanine catabolic process
D	0006571	biological_process	L-tyrosine biosynthetic process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 1260

Chain	Residue
A	ILE86
A	PHE91
A	PEG1261
A	PEG1262

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 1260

Chain	Residue
B	TYR215
B	PEG1261
B	PEG1262
B	HOH2048
B	HOH2049

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 1261

Chain	Residue
B	PHE91
B	TRP163
B	GLU167
B	PEG1260
B	PEG1262

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 1262

Chain	Residue
B	GLN116
B	PRO118
B	PEG1260
B	PEG1261
B	HOH2050

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 1261

Chain	Residue
A	TRP163
A	GLU167
A	PEG1260
A	PEG1262

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 1262

Chain	Residue
A	GLN159
A	TRP163
A	TYR215
A	ILE217
A	PEG1260
A	PEG1261

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Functional Information from PROSITE/UniProt

site_id	PS00367
Number of Residues	12
Details	BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDifHELFGHCP

Chain	Residue	Details
A	PRO118-PRO129

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