4BPT

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0004505	molecular_function	phenylalanine 4-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006559	biological_process	L-phenylalanine catabolic process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
A	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0004505	molecular_function	phenylalanine 4-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0006559	biological_process	L-phenylalanine catabolic process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
B	0046872	molecular_function	metal ion binding
C	0004497	molecular_function	monooxygenase activity
C	0004505	molecular_function	phenylalanine 4-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0006559	biological_process	L-phenylalanine catabolic process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
C	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
C	0046872	molecular_function	metal ion binding
D	0004497	molecular_function	monooxygenase activity
D	0004505	molecular_function	phenylalanine 4-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0006559	biological_process	L-phenylalanine catabolic process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
D	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 1260

Chain	Residue
A	ILE86
A	PHE91
A	PEG1261
A	PEG1262

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 1260

Chain	Residue
B	TYR215
B	PEG1261
B	PEG1262
B	HOH2048
B	HOH2049

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 1261

Chain	Residue
B	PHE91
B	TRP163
B	GLU167
B	PEG1260
B	PEG1262

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 1262

Chain	Residue
B	GLN116
B	PRO118
B	PEG1260
B	PEG1261
B	HOH2050

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 1261

Chain	Residue
A	TRP163
A	GLU167
A	PEG1260
A	PEG1262

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 1262

Chain	Residue
A	GLN159
A	TRP163
A	TYR215
A	ILE217
A	PEG1260
A	PEG1261

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Functional Information from PROSITE/UniProt

site_id	PS00367
Number of Residues	12
Details	BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDifHELFGHCP

Chain	Residue	Details
A	PRO118-PRO129

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