4BOZ

Structure of OTUD2 OTU domain in complex with K11-linked di ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
A	0030433	biological_process	ubiquitin-dependent ERAD pathway
A	0101005	molecular_function	deubiquitinase activity
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0016579	biological_process	protein deubiquitination
D	0030433	biological_process	ubiquitin-dependent ERAD pathway
D	0101005	molecular_function	deubiquitinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1309

Chain	Residue
A	ALA187
A	GLN188
A	CYS210
A	LYS214

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 1312

Chain	Residue
D	ARG184
D	GLN188
D	LYS214

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	250
Details	Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"Cys-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Region: {"description":"Variable-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Region: {"description":"His-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Region: {"description":"S2 site","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q96FW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BOS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	150
Details	Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---