Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0030433 | biological_process | ubiquitin-dependent ERAD pathway |
| A | 0101005 | molecular_function | deubiquitinase activity |
| B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| B | 0016579 | biological_process | protein deubiquitination |
| B | 0030433 | biological_process | ubiquitin-dependent ERAD pathway |
| B | 0101005 | molecular_function | deubiquitinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 B 1310 |
| Chain | Residue |
| A | TRP212 |
| B | ALA156 |
| B | ASP157 |
| B | ASN158 |
| B | SER159 |
| B | ALA160 |
| B | HIS267 |
| B | HOH2022 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 B 1311 |
| Chain | Residue |
| B | GLY265 |
| B | HOH2068 |
| B | HOH2079 |
| B | TYR263 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1312 |
| Chain | Residue |
| B | GLU251 |
| B | GLU251 |
| B | GLU251 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 C 1077 |
| Chain | Residue |
| A | HOH2047 |
| A | HOH2082 |
| A | HOH2083 |
| C | LEU71 |
| C | HOH2019 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 C 1078 |
| Chain | Residue |
| A | ALA222 |
| C | THR7 |
| C | LEU8 |
| C | THR9 |
| C | LEU69 |
| C | VAL70 |
| C | LEU71 |
| C | HOH2003 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 F 1014 |
| Chain | Residue |
| A | HIS267 |
| A | ARG306 |
| A | ARG307 |
| F | THR9 |
| F | GLY10 |
| F | LYS11 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| C | LYS27-ASP52 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 250 |
| Details | Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Region: {"description":"Cys-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Region: {"description":"Variable-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Region: {"description":"His-loop","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Region: {"description":"S2 site","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"Q96FW1","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23827681","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BOS","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 75 |
| Details | Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
