4BO4

Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2-methoxyphenyl)-3,4- dihydro-2H-quinoline-1-carboxamide at 2.7A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0030497	biological_process	fatty acid elongation
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0030497	biological_process	fatty acid elongation
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0030497	biological_process	fatty acid elongation
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0030497	biological_process	fatty acid elongation
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 36G A 1248

Chain	Residue
A	TRP106
B	ALA156
B	GLY163
A	PHE107
A	ASN111
A	LEU114
A	GLY160
A	GLY163
A	PHE164
B	PHE107
B	LEU114

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 36G C 1248

Chain	Residue
C	TRP106
C	ASN111
C	LEU114
C	GLY160
C	PHE164
D	PHE107
D	VAL110
D	ALA159
D	GLY160

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Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgamgnagQtnYAAAKAGLeGFTrALA

Chain	Residue	Details
A	SER141-ALA169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR154
B	TYR154
C	TYR154
D	TYR154

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	SER141
A	TYR154
A	ILE187
B	GLY12
B	THR37
B	ASP62
B	ASN89
B	SER141
B	TYR154
B	ILE187
C	GLY12
C	THR37
C	ASP62
C	ASN89
C	SER141
C	TYR154
C	ILE187
D	GLY12
D	THR37
D	ASP62
D	ASN89
D	SER141
D	TYR154
D	ILE187
A	GLY12
A	THR37
A	ASP62
A	ASN89

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