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4BL8

Crystal structure of full-length human Suppressor of fused (SUFU)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001843biological_processneural tube closure
A0001947biological_processheart looping
A0003281biological_processventricular septum development
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005929cellular_componentcilium
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0007224biological_processsmoothened signaling pathway
A0007286biological_processspermatid development
A0007368biological_processdetermination of left/right symmetry
A0008013molecular_functionbeta-catenin binding
A0008643biological_processcarbohydrate transport
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0021513biological_processspinal cord dorsal/ventral patterning
A0021775biological_processsmoothened signaling pathway involved in ventral spinal cord interneuron specification
A0021776biological_processsmoothened signaling pathway involved in spinal cord motor neuron cell fate specification
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0035904biological_processaorta development
A0042308biological_processnegative regulation of protein import into nucleus
A0042597cellular_componentperiplasmic space
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0043588biological_processskin development
A0045668biological_processnegative regulation of osteoblast differentiation
A0045879biological_processnegative regulation of smoothened signaling pathway
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0060976biological_processcoronary vasculature development
A0097542cellular_componentciliary tip
A0097546cellular_componentciliary base
A1901982molecular_functionmaltose binding
A1990060cellular_componentmaltose transport complex
A1990788cellular_componentGLI-SUFU complex
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
A2001040biological_processpositive regulation of cellular response to drug
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001843biological_processneural tube closure
B0001947biological_processheart looping
B0003281biological_processventricular septum development
B0003714molecular_functiontranscription corepressor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005929cellular_componentcilium
B0006355biological_processregulation of DNA-templated transcription
B0006974biological_processDNA damage response
B0007165biological_processsignal transduction
B0007224biological_processsmoothened signaling pathway
B0007286biological_processspermatid development
B0007368biological_processdetermination of left/right symmetry
B0008013molecular_functionbeta-catenin binding
B0008643biological_processcarbohydrate transport
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0019901molecular_functionprotein kinase binding
B0021513biological_processspinal cord dorsal/ventral patterning
B0021775biological_processsmoothened signaling pathway involved in ventral spinal cord interneuron specification
B0021776biological_processsmoothened signaling pathway involved in spinal cord motor neuron cell fate specification
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034219biological_processcarbohydrate transmembrane transport
B0034289biological_processdetection of maltose stimulus
B0035904biological_processaorta development
B0042308biological_processnegative regulation of protein import into nucleus
B0042597cellular_componentperiplasmic space
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0043433biological_processnegative regulation of DNA-binding transcription factor activity
B0043588biological_processskin development
B0045668biological_processnegative regulation of osteoblast differentiation
B0045879biological_processnegative regulation of smoothened signaling pathway
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B0060976biological_processcoronary vasculature development
B0097542cellular_componentciliary tip
B0097546cellular_componentciliary base
B1901982molecular_functionmaltose binding
B1990060cellular_componentmaltose transport complex
B1990788cellular_componentGLI-SUFU complex
B2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
B2001040biological_processpositive regulation of cellular response to drug
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO108-ASN125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER641
BSER641

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS643
BLYS643

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:27234298, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER682
ASER686
BSER682
BSER686

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:27234298
ChainResidueDetails
ASER692
BSER692

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:27234298
ChainResidueDetails
ATHR693
BTHR693

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER821
BSER821

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27234298
ChainResidueDetails
ALYS597
BLYS597

site_idSWS_FT_FI8
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS661
BLYS661

224201

PDB entries from 2024-08-28

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