4BC5

Crystal structure of human D-xylulokinase in complex with inhibitor 5- deoxy-5-fluoro-D-xylulose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004856	molecular_function	D-xylulokinase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0005997	biological_process	xylulose metabolic process
A	0005998	biological_process	xylulose catabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019640	biological_process	D-glucuronate catabolic process to D-xylulose 5-phosphate
A	0042732	biological_process	D-xylose metabolic process
A	0046835	biological_process	carbohydrate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0004856	molecular_function	D-xylulokinase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0005997	biological_process	xylulose metabolic process
B	0005998	biological_process	xylulose catabolic process
B	0006091	biological_process	generation of precursor metabolites and energy
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019640	biological_process	D-glucuronate catabolic process to D-xylulose 5-phosphate
B	0042732	biological_process	D-xylose metabolic process
B	0046835	biological_process	carbohydrate phosphorylation
C	0000166	molecular_function	nucleotide binding
C	0004856	molecular_function	D-xylulokinase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0005997	biological_process	xylulose metabolic process
C	0005998	biological_process	xylulose catabolic process
C	0006091	biological_process	generation of precursor metabolites and energy
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019640	biological_process	D-glucuronate catabolic process to D-xylulose 5-phosphate
C	0042732	biological_process	D-xylose metabolic process
C	0046835	biological_process	carbohydrate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 5FX A 1531

Chain	Residue
A	GLN97
A	GLN98
A	HIS99
A	TRP137
A	ARG170
A	ASP280
A	ASN281
A	HOH2009

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 5FX C 1532

Chain	Residue
C	GLN97
C	GLN98
C	HIS99
C	TRP137
C	ARG170
C	ASP280
C	ASN281
C	HOH2007
C	THR17

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 5FX B 1532

Chain	Residue
B	GLN97
B	GLN98
B	HIS99
B	TRP137
B	ARG170
B	ASP280
B	ASN281
B	HOH2253

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 1533

Chain	Residue
C	SER251
C	CYS252
C	PRO324
C	VAL325
C	ASP326
C	SER327

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {}

Chain

Residue

Details

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