4BBQ
Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1677 |
| Chain | Residue |
| A | ASP657 |
| A | GLY658 |
| A | HOH2049 |
| B | LYS601 |
| B | GLN602 |
| B | HOH2006 |
| B | HOH2029 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1677 |
| Chain | Residue |
| B | CYS588 |
| B | CYS604 |
| B | CYS582 |
| B | CYS585 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1678 |
| Chain | Residue |
| A | CYS582 |
| A | CYS585 |
| A | CYS588 |
| A | CYS604 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1679 |
| Chain | Residue |
| A | CYS571 |
| A | CYS574 |
| A | CYS577 |
| A | CYS609 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1678 |
| Chain | Residue |
| B | CYS571 |
| B | CYS574 |
| B | CYS577 |
| B | CYS609 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1680 |
| Chain | Residue |
| A | CYS642 |
| A | CYS645 |
| A | CYS672 |
| A | CYS675 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1681 |
| Chain | Residue |
| A | CYS620 |
| A | CYS623 |
| A | HIS650 |
| A | CYS653 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1679 |
| Chain | Residue |
| B | CYS642 |
| B | CYS645 |
| B | CYS672 |
| B | CYS675 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1680 |
| Chain | Residue |
| B | CYS620 |
| B | CYS623 |
| B | HIS650 |
| B | CYS653 |
Functional Information from PROSITE/UniProt
| site_id | PS00197 |
| Number of Residues | 9 |
| Details | 2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CVQGECGVC |
| Chain | Residue | Details |
| A | CYS577-CYS585 |
| site_id | PS01359 |
| Number of Residues | 56 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CslCgevdqneetqdfekklm............................EcCi...Cnei.VHpgClqmdgegllneelpnc.............................WeCpkC |
| Chain | Residue | Details |
| A | CYS620-CYS675 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00509","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2012","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Cxxc and Phd Domain of Human Lysine-Specific Demethylase 2A (Kdm2A)(Fbxl11).","authors":["Allerston C.K.","Watson A.A.","Edlich C.","Li B.","Chen Y.","Ball L.","Krojer T.","Arrowsmith C.H.","Edwards A.","Bountra C.","von Delft F.","Laue E.D.","Gileadi O."]}},{"source":"PDB","id":"4BBQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2012","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Cxxc and Phd Domain of Human Lysine-Specific Demethylase 2A (Kdm2A)(Fbxl11).","authors":["Allerston C.K.","Watson A.A.","Edlich C.","Li B.","Chen Y.","Ball L.","Krojer T.","Arrowsmith C.H.","Edwards A.","Bountra C.","von Delft F.","Laue E.D.","Gileadi O."]}},{"source":"PDB","id":"4BBQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
