4B86

Crystal structure of the MSL1-MSL2 complex (3.5A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0072487	cellular_component	MSL complex
B	0072487	cellular_component	MSL complex
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0072487	cellular_component	MSL complex
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0072487	cellular_component	MSL complex
E	0072487	cellular_component	MSL complex
F	0072487	cellular_component	MSL complex
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0072487	cellular_component	MSL complex
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0072487	cellular_component	MSL complex
I	0072487	cellular_component	MSL complex
J	0072487	cellular_component	MSL complex
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0072487	cellular_component	MSL complex
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0072487	cellular_component	MSL complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 201

Chain	Residue
C	CYS44
C	CYS47
C	CYS67
C	CYS70

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 202

Chain	Residue
C	CYS62
C	HIS64
C	CYS81
C	CYS84

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 201

Chain	Residue
D	CYS47
D	CYS67
D	CYS70
D	CYS44

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 202

Chain	Residue
D	CYS62
D	HIS64

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 201

Chain	Residue
G	CYS44
G	CYS47
G	CYS67
G	CYS70

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 202

Chain	Residue
G	CYS62
G	HIS64
G	CYS81
G	CYS84

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 201

Chain	Residue
H	CYS44
H	CYS47
H	CYS67
H	CYS70

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN H 202

Chain	Residue
H	CYS62
H	HIS64

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 201

Chain	Residue
K	CYS44
K	CYS47
K	CYS67
K	CYS70

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN K 202

Chain	Residue
K	CYS62
K	HIS64

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 201

Chain	Residue
L	CYS44
L	CYS47
L	CYS67
L	CYS70

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 202

Chain	Residue
L	CYS62
L	HIS64
L	CYS81
L	CYS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	246
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
C	CYS44-LYS85
D	CYS44-LYS85
G	CYS44-LYS85
H	CYS44-LYS85
K	CYS44-LYS85
L	CYS44-LYS85

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:23084835, ECO:0007744|PDB:4B7Y, ECO:0007744|PDB:4B86

Chain	Residue	Details
C	CYS44
D	CYS47
D	CYS62
D	HIS64
D	CYS67
D	CYS70
D	CYS81
D	CYS84
G	CYS44
G	CYS47
G	CYS62
C	CYS47
G	HIS64
G	CYS67
G	CYS70
G	CYS81
G	CYS84
H	CYS44
H	CYS47
H	CYS62
H	HIS64
H	CYS67
C	CYS62
H	CYS70
H	CYS81
H	CYS84
K	CYS44
K	CYS47
K	CYS62
K	HIS64
K	CYS67
K	CYS70
K	CYS81
C	HIS64
K	CYS84
L	CYS44
L	CYS47
L	CYS62
L	HIS64
L	CYS67
L	CYS70
L	CYS81
L	CYS84
C	CYS67
C	CYS70
C	CYS81
C	CYS84
D	CYS44

---