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4B7U

PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH BICINE

Replaces:  2YDN
Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004459molecular_functionL-lactate dehydrogenase activity
A0006089biological_processlactate metabolic process
A0006090biological_processpyruvate metabolic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019752biological_processcarboxylic acid metabolic process
A0046872molecular_functionmetal ion binding
B0003824molecular_functioncatalytic activity
B0004459molecular_functionL-lactate dehydrogenase activity
B0006089biological_processlactate metabolic process
B0006090biological_processpyruvate metabolic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019752biological_processcarboxylic acid metabolic process
B0046872molecular_functionmetal ion binding
C0003824molecular_functioncatalytic activity
C0004459molecular_functionL-lactate dehydrogenase activity
C0006089biological_processlactate metabolic process
C0006090biological_processpyruvate metabolic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0019752biological_processcarboxylic acid metabolic process
C0046872molecular_functionmetal ion binding
D0003824molecular_functioncatalytic activity
D0004459molecular_functionL-lactate dehydrogenase activity
D0006089biological_processlactate metabolic process
D0006090biological_processpyruvate metabolic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0019752biological_processcarboxylic acid metabolic process
D0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE BCN A 1331
ChainResidue
AASN140
AARG171
AHIS195
AALA236
ACA401
AHOH2136
AHOH2265

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BCN B 1331
ChainResidue
BARG171
BHIS195
BALA236
BSER245
BPRO246
BCA401
BHOH2095
BASN140
BLEU167

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BCN B 1332
ChainResidue
ALYS129
AASN130
APRO132
BPHE52
BTHR84
BTYR85
BGLU122
BHIS126
BHOH2048

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE BCN B 1333
ChainResidue
AALA91
AASP92
AASN132
ALYS159
AHOH2065
BASP86
BALA89
BASN130

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BCN C 1331
ChainResidue
CASN140
CLEU167
CARG171
CHIS195
CALA236
CSER245
CPRO246
CCA401
CHOH2105

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE BCN D 1332
ChainResidue
DASN140
DARG171
DHIS195
DALA236
DCA401
DHOH2066
DHOH2085

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE BCN D 1333
ChainResidue
CASP86
CLYS129
CASN130
DALA91
DASP92
DASN132
DLYS159
DHOH2041

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE BCN D 1334
ChainResidue
AGLY103
AHOH2081
DGLY29
DMET30
DTHR101
DSER245
DHOH2007
DHOH2171

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 401
ChainResidue
AASN140
AHIS195
ABCN1331
AHOH2120

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MPD A 1332
ChainResidue
ALEU115
ALYS118
DASN83
DTHR84
DTYR85
DHOH2036

site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 1333
ChainResidue
BGLY125
BHIS126

site_idBC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE EDO A 1334
ChainResidue
AGLY125

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 401
ChainResidue
BASN140
BHIS195
BBCN1331
BHOH2076

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA C 401
ChainResidue
CASN140
CHIS195
CBCN1331
CHOH2085

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA D 401
ChainResidue
DASN140
DHIS195
DBCN1332
DHOH2070

site_idBC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO D 1335
ChainResidue
DGLU122
DGLY125

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PDB entries from 2024-11-13

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