4B7S
PikC D50N mutant bound to the 10-DML analog with the 3-(N,N- dimethylamino)propanoate anchoring group
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0017000 | biological_process | antibiotic biosynthetic process |
A | 0020037 | molecular_function | heme binding |
A | 0033068 | biological_process | macrolide biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0055114 | biological_process | obsolete oxidation-reduction process |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
B | 0017000 | biological_process | antibiotic biosynthetic process |
B | 0020037 | molecular_function | heme binding |
B | 0033068 | biological_process | macrolide biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0055114 | biological_process | obsolete oxidation-reduction process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE HEM A 1407 |
Chain | Residue |
A | LYS72 |
A | THR248 |
A | LEU251 |
A | PRO289 |
A | ALA293 |
A | THR294 |
A | ARG296 |
A | ALA346 |
A | PHE347 |
A | GLY348 |
A | ILE351 |
A | MET92 |
A | HIS352 |
A | CYS354 |
A | ILE355 |
A | GLY356 |
A | ALA360 |
A | HOH2373 |
A | LEU93 |
A | HIS100 |
A | ARG104 |
A | PHE111 |
A | ILE157 |
A | GLY244 |
A | THR247 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE QLE A 1408 |
Chain | Residue |
A | GLU85 |
A | GLU94 |
A | PHE178 |
A | VAL179 |
A | HIS238 |
A | ILE239 |
A | VAL242 |
A | ALA243 |
A | THR294 |
A | MET394 |
A | ILE395 |
A | GOL1415 |
site_id | AC3 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEM B 1407 |
Chain | Residue |
B | MET92 |
B | LEU93 |
B | HIS100 |
B | ARG104 |
B | PHE111 |
B | ALA243 |
B | GLY244 |
B | THR247 |
B | THR248 |
B | LEU251 |
B | PRO289 |
B | ALA293 |
B | THR294 |
B | ARG296 |
B | ALA346 |
B | PHE347 |
B | GLY348 |
B | ILE351 |
B | HIS352 |
B | CYS354 |
B | ILE355 |
B | ALA360 |
B | HOH2307 |
site_id | AC4 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE QLE B 1408 |
Chain | Residue |
B | GLU85 |
B | ASN89 |
B | LEU93 |
B | GLU94 |
B | PHE178 |
B | VAL179 |
B | HIS238 |
B | ILE239 |
B | VAL242 |
B | ALA243 |
B | GLU246 |
B | THR247 |
B | THR294 |
B | MET394 |
B | ILE395 |
B | GOL1411 |
B | HOH2194 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1409 |
Chain | Residue |
A | LEU106 |
A | THR220 |
A | ARG227 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1410 |
Chain | Residue |
A | ARG114 |
A | ARG115 |
A | HOH2186 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 1411 |
Chain | Residue |
A | VAL173 |
A | GLU193 |
A | HOH2396 |
A | HOH2397 |
A | HOH2398 |
B | ARG75 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 1409 |
Chain | Residue |
B | THR112 |
B | ARG114 |
B | HOH2143 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 1410 |
Chain | Residue |
B | HIS262 |
B | PRO263 |
B | ASP264 |
B | GLN265 |
B | ARG334 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1412 |
Chain | Residue |
A | HOH2044 |
A | ARG36 |
A | PRO326 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1413 |
Chain | Residue |
A | ARG75 |
A | HIS90 |
A | ARG99 |
A | HOH2117 |
A | HOH2157 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1414 |
Chain | Residue |
A | GLU223 |
A | ASP224 |
A | HOH2304 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1415 |
Chain | Residue |
A | THR294 |
A | TYR295 |
A | QLE1408 |
A | HOH2122 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 1411 |
Chain | Residue |
B | THR294 |
B | TYR295 |
B | MET394 |
B | QLE1408 |
B | HOH2115 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 1416 |
Chain | Residue |
A | PRO98 |
A | ARG99 |
A | ARG102 |
A | HOH2167 |
A | HOH2399 |
site_id | BC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 1417 |
Chain | Residue |
A | TYR29 |
A | ASN254 |
A | TYR257 |
A | TYR286 |
A | GLU287 |
A | ARG324 |
A | TRP389 |
A | ARG396 |
A | HOH2339 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 1418 |
Chain | Residue |
A | ARG361 |
A | ARG365 |
A | HOH2382 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1419 |
Chain | Residue |
A | ARG62 |
A | HIS349 |
A | HOH2401 |
A | HOH2402 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 1420 |
Chain | Residue |
A | VAL14 |
A | LEU15 |
A | ARG34 |
A | GLU38 |
A | HOH2048 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGIHFCIG |
Chain | Residue | Details |
A | PHE347-GLY356 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16825192, ECO:0000269|PubMed:19124459 |
Chain | Residue | Details |
A | GLU94 | |
A | ALA187 | |
A | HIS238 | |
B | GLU94 | |
B | ALA187 | |
B | HIS238 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:16825192, ECO:0000269|PubMed:19124459, ECO:0000269|PubMed:19833867, ECO:0000269|PubMed:24627965, ECO:0000312|PDB:2C6H, ECO:0000312|PDB:2C7X, ECO:0000312|PDB:2CA0, ECO:0000312|PDB:2CD8, ECO:0000312|PDB:2VZ7, ECO:0000312|PDB:2VZM, ECO:0000312|PDB:2WHW, ECO:0000312|PDB:2WI9, ECO:0000312|PDB:3ZK5, ECO:0000312|PDB:4B7D, ECO:0000312|PDB:4B7S, ECO:0000312|PDB:4BF4 |
Chain | Residue | Details |
A | CYS354 | |
B | CYS354 |