4B5P
Crystal structure of human alpha tubulin acetyltransferase catalytic domain Q58A variant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005874 | cellular_component | microtubule |
| A | 0019799 | molecular_function | tubulin N-acetyltransferase activity |
| A | 0071929 | biological_process | alpha-tubulin acetylation |
| B | 0005874 | cellular_component | microtubule |
| B | 0019799 | molecular_function | tubulin N-acetyltransferase activity |
| B | 0071929 | biological_process | alpha-tubulin acetylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 401 |
| Chain | Residue |
| A | ALA57 |
| A | GLU128 |
| A | GLN131 |
| A | LYS162 |
| A | ACO1197 |
| B | LYS162 |
| B | NA401 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA B 401 |
| Chain | Residue |
| B | ALA57 |
| B | GLU128 |
| B | GLN131 |
| B | LYS162 |
| B | ACO1197 |
| A | LYS162 |
| A | NA401 |
| site_id | AC3 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE ACO A 1197 |
| Chain | Residue |
| A | ILE121 |
| A | ASP123 |
| A | PHE124 |
| A | TYR125 |
| A | ILE126 |
| A | GLN131 |
| A | ARG132 |
| A | HIS133 |
| A | GLY134 |
| A | GLY136 |
| A | ARG137 |
| A | ASP157 |
| A | SER160 |
| A | LYS162 |
| A | LYS165 |
| A | PHE166 |
| A | LYS169 |
| A | HIS170 |
| A | NA401 |
| A | HOH2111 |
| A | HOH2112 |
| A | HOH2113 |
| A | HOH2115 |
| A | HOH2120 |
| A | HOH2159 |
| A | HOH2160 |
| A | HOH2161 |
| A | HOH2162 |
| A | HOH2163 |
| A | HOH2164 |
| A | HOH2165 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE ACO B 1197 |
| Chain | Residue |
| A | HOH2054 |
| B | ILE121 |
| B | ASP123 |
| B | PHE124 |
| B | TYR125 |
| B | ILE126 |
| B | GLN131 |
| B | ARG132 |
| B | HIS133 |
| B | GLY134 |
| B | GLY136 |
| B | ARG137 |
| B | ILE156 |
| B | ASP157 |
| B | ARG158 |
| B | SER160 |
| B | LYS162 |
| B | LEU163 |
| B | LYS165 |
| B | PHE166 |
| B | LYS169 |
| B | HIS170 |
| B | NA401 |
| B | HOH2108 |
| B | HOH2109 |
| B | HOH2111 |
| B | HOH2113 |
| B | HOH2114 |
| B | HOH2116 |
| B | HOH2118 |
| B | HOH2180 |
| B | HOH2181 |
| B | HOH2182 |
| B | HOH2183 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03130","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23071318","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24906155","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_03130","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071318","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q8K341","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03130","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
