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4B2Z

Structure of Osh6 in complex with phosphatidylserine

Functional Information from GO Data
ChainGOidnamespacecontents
A0001786molecular_functionphosphatidylserine binding
A0005548molecular_functionphospholipid transporter activity
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0006887biological_processexocytosis
A0006897biological_processendocytosis
A0008289molecular_functionlipid binding
A0010314molecular_functionphosphatidylinositol-5-phosphate binding
A0015914biological_processphospholipid transport
A0015918biological_processsterol transport
A0016020cellular_componentmembrane
A0016125biological_processsterol metabolic process
A0030011biological_processmaintenance of cell polarity
A0032541cellular_componentcortical endoplasmic reticulum
A0032934molecular_functionsterol binding
A0034727biological_processpiecemeal microautophagy of the nucleus
A0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
A0055092biological_processsterol homeostasis
A0070273molecular_functionphosphatidylinositol-4-phosphate binding
A0070300molecular_functionphosphatidic acid binding
A0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
A0120015molecular_functionsterol transfer activity
B0001786molecular_functionphosphatidylserine binding
B0005548molecular_functionphospholipid transporter activity
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0006887biological_processexocytosis
B0006897biological_processendocytosis
B0008289molecular_functionlipid binding
B0010314molecular_functionphosphatidylinositol-5-phosphate binding
B0015914biological_processphospholipid transport
B0015918biological_processsterol transport
B0016020cellular_componentmembrane
B0016125biological_processsterol metabolic process
B0030011biological_processmaintenance of cell polarity
B0032541cellular_componentcortical endoplasmic reticulum
B0032934molecular_functionsterol binding
B0034727biological_processpiecemeal microautophagy of the nucleus
B0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
B0055092biological_processsterol homeostasis
B0070273molecular_functionphosphatidylinositol-4-phosphate binding
B0070300molecular_functionphosphatidic acid binding
B0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
B0120015molecular_functionsterol transfer activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1435
ChainResidue
ALEU132
AGLY133
APHE372
ALYS375
AHOH2059
AHOH2145
AHOH2167

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 B 1435
ChainResidue
BGLN154
BPRO160
BGLU161
BCYS162
BVAL179
BPRO181
BHOH2061
BMET79
BPRO130

site_idAC3
Number of Residues26
DetailsBINDING SITE FOR RESIDUE P5S A 1436
ChainResidue
ALEU64
AILE67
ALEU69
AILE73
AMET79
AARG82
AGLN86
ATRP112
ALYS125
ALYS126
APRO127
AASN129
APRO160
ASER183
ASER190
AALA191
AALA192
AMET194
ATHR198
AVAL222
AMET232
AILE234
AHOH2049
AHOH2054
AHOH2055
AHOH2087

site_idAC4
Number of Residues26
DetailsBINDING SITE FOR RESIDUE P5S B 1436
ChainResidue
BLEU64
BILE67
BTHR68
BLEU69
BMET79
BGLN86
BTRP112
BTYR113
BVAL124
BLYS126
BPRO127
BASN129
BPRO160
BTYR164
BSER183
BSER190
BALA191
BALA192
BTHR198
BVAL222
BMET232
BHOH2055
BHOH2061
BHOH2062
BHOH2063
BHOH2096

site_idAC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE DTU A 1437
ChainResidue
ALEU408
AGLN409
APRO412
AGLN417
AGLN418
APHE419
ATHR420
ALYS422
APHE423
AHOH2158

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DTT B 1437
ChainResidue
ALYS243
ASER244
APRO245
ATYR273
BGLY61
BARG184
BLEU186
BMET193

Functional Information from PROSITE/UniProt
site_idPS01013
Number of Residues12
DetailsOSBP Oxysterol-binding protein family signature. EQtSHHPPecAY
ChainResidueDetails
AGLU153-TYR164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:23934110, ECO:0007744|PDB:4B2Z
ChainResidueDetails
ALEU64
AASN129
ASER183
BLEU64
BASN129
BSER183

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:26206936, ECO:0007744|PDB:4PH7
ChainResidueDetails
ALYS126
BARG359
AHIS157
ALYS351
AGLU355
AARG359
BLYS126
BHIS157
BLYS351
BGLU355

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358
ChainResidueDetails
ASER16
BSER16

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PDB entries from 2024-11-06

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