4B2Z
Structure of Osh6 in complex with phosphatidylserine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005548 | molecular_function | phospholipid transporter activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0006887 | biological_process | exocytosis |
| A | 0006897 | biological_process | endocytosis |
| A | 0008289 | molecular_function | lipid binding |
| A | 0010314 | molecular_function | phosphatidylinositol-5-phosphate binding |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0015918 | biological_process | sterol transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016125 | biological_process | sterol metabolic process |
| A | 0030011 | biological_process | maintenance of cell polarity |
| A | 0032541 | cellular_component | cortical endoplasmic reticulum |
| A | 0032934 | molecular_function | sterol binding |
| A | 0034727 | biological_process | piecemeal microautophagy of the nucleus |
| A | 0043325 | molecular_function | phosphatidylinositol-3,4-bisphosphate binding |
| A | 0055092 | biological_process | sterol homeostasis |
| A | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| A | 0070300 | molecular_function | phosphatidic acid binding |
| A | 0080025 | molecular_function | phosphatidylinositol-3,5-bisphosphate binding |
| A | 0120015 | molecular_function | sterol transfer activity |
| B | 0001786 | molecular_function | phosphatidylserine binding |
| B | 0005548 | molecular_function | phospholipid transporter activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006869 | biological_process | lipid transport |
| B | 0006887 | biological_process | exocytosis |
| B | 0006897 | biological_process | endocytosis |
| B | 0008289 | molecular_function | lipid binding |
| B | 0010314 | molecular_function | phosphatidylinositol-5-phosphate binding |
| B | 0015914 | biological_process | phospholipid transport |
| B | 0015918 | biological_process | sterol transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016125 | biological_process | sterol metabolic process |
| B | 0030011 | biological_process | maintenance of cell polarity |
| B | 0032541 | cellular_component | cortical endoplasmic reticulum |
| B | 0032934 | molecular_function | sterol binding |
| B | 0034727 | biological_process | piecemeal microautophagy of the nucleus |
| B | 0043325 | molecular_function | phosphatidylinositol-3,4-bisphosphate binding |
| B | 0055092 | biological_process | sterol homeostasis |
| B | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| B | 0070300 | molecular_function | phosphatidic acid binding |
| B | 0080025 | molecular_function | phosphatidylinositol-3,5-bisphosphate binding |
| B | 0120015 | molecular_function | sterol transfer activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1435 |
| Chain | Residue |
| A | LEU132 |
| A | GLY133 |
| A | PHE372 |
| A | LYS375 |
| A | HOH2059 |
| A | HOH2145 |
| A | HOH2167 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1435 |
| Chain | Residue |
| B | GLN154 |
| B | PRO160 |
| B | GLU161 |
| B | CYS162 |
| B | VAL179 |
| B | PRO181 |
| B | HOH2061 |
| B | MET79 |
| B | PRO130 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE P5S A 1436 |
| Chain | Residue |
| A | LEU64 |
| A | ILE67 |
| A | LEU69 |
| A | ILE73 |
| A | MET79 |
| A | ARG82 |
| A | GLN86 |
| A | TRP112 |
| A | LYS125 |
| A | LYS126 |
| A | PRO127 |
| A | ASN129 |
| A | PRO160 |
| A | SER183 |
| A | SER190 |
| A | ALA191 |
| A | ALA192 |
| A | MET194 |
| A | THR198 |
| A | VAL222 |
| A | MET232 |
| A | ILE234 |
| A | HOH2049 |
| A | HOH2054 |
| A | HOH2055 |
| A | HOH2087 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE P5S B 1436 |
| Chain | Residue |
| B | LEU64 |
| B | ILE67 |
| B | THR68 |
| B | LEU69 |
| B | MET79 |
| B | GLN86 |
| B | TRP112 |
| B | TYR113 |
| B | VAL124 |
| B | LYS126 |
| B | PRO127 |
| B | ASN129 |
| B | PRO160 |
| B | TYR164 |
| B | SER183 |
| B | SER190 |
| B | ALA191 |
| B | ALA192 |
| B | THR198 |
| B | VAL222 |
| B | MET232 |
| B | HOH2055 |
| B | HOH2061 |
| B | HOH2062 |
| B | HOH2063 |
| B | HOH2096 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE DTU A 1437 |
| Chain | Residue |
| A | LEU408 |
| A | GLN409 |
| A | PRO412 |
| A | GLN417 |
| A | GLN418 |
| A | PHE419 |
| A | THR420 |
| A | LYS422 |
| A | PHE423 |
| A | HOH2158 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DTT B 1437 |
| Chain | Residue |
| A | LYS243 |
| A | SER244 |
| A | PRO245 |
| A | TYR273 |
| B | GLY61 |
| B | ARG184 |
| B | LEU186 |
| B | MET193 |
Functional Information from PROSITE/UniProt
| site_id | PS01013 |
| Number of Residues | 12 |
| Details | OSBP Oxysterol-binding protein family signature. EQtSHHPPecAY |
| Chain | Residue | Details |
| A | GLU153-TYR164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 674 |
| Details | Region: {"description":"OSBP-related domain (ORD)","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23934110","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4B2Z","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26206936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PH7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
