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4B0A

The high-resolution structure of yTBP-yTAF1 identifies conserved and competing interaction surfaces in transcriptional activation

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0006352biological_processDNA-templated transcription initiation
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CA A 1067
ChainResidue
AGLY37
AASP39
AGLU288
AHOH2041
AHOH2042
AHOH2045
AHOH2081

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 1068
ChainResidue
AASN195
AHOH2046
AHOH2053
AHOH2054
AASP39
AASP46

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 1069
ChainResidue
AASP16
ATYR19
AGLU20
AGLU49
AHIS50
AARG190
ALYS220
AHOH2015

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1070
ChainResidue
ATYR19
APHE23
AARG190
AGLN258
AHOH2065
AHOH2066

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 1071
ChainResidue
AGLU20
AASP39
AGLU40
AALA41
AASP46
ATYR47
AHOH2047
AHOH2049
AHOH2055

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1241
ChainResidue
AGLU26
APHE27
AARG296
ALYS301
AVAL303
AGLY316
AHOH2027

site_idAC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 1242
ChainResidue
AILE36
ALYS210
ATHR211
ATHR212
AGLY225
AGOL1243
AHOH2126
AHOH2133
AHOH2208
AHOH2210

site_idAC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 1243
ChainResidue
AILE32
AGLY33
AILE36
AASN169
ATHR224
AGLY225
AGOL1242
AHOH2033
AHOH2211
AHOH2212

site_idAC9
Number of Residues9
DetailsBINDING SITE FOR RESIDUE CA A 1244
ChainResidue
AGLU31
AGLY280
ASER283
AHOH2163
AHOH2166
AHOH2167
AHOH2168
AHOH2172
AHOH2173

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 1245
ChainResidue
ALEU12
AARG271
AGLY274

Functional Information from PROSITE/UniProt
site_idPS00351
Number of Residues50
DetailsTFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePKttaLIFaSGKMvvtGAKseddsklAsrkyariI
ChainResidueDetails
ATYR194-ILE243
ATYR285-LEU334

226707

PDB entries from 2024-10-30

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