4AZC
Differential inhibition of the tandem GH20 catalytic modules in the pneumococcal exo-beta-D-N-acetylglucosaminidase, StrH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005975 | biological_process | carbohydrate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NGW A 2042 |
| Chain | Residue |
| A | ARG641 |
| A | ASP953 |
| A | HOH3055 |
| A | HIS742 |
| A | ASP804 |
| A | GLU805 |
| A | PHE849 |
| A | TRP872 |
| A | TYR902 |
| A | ILE904 |
| A | TRP951 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NGW B 2044 |
| Chain | Residue |
| B | ARG641 |
| B | HIS742 |
| B | ASP804 |
| B | GLU805 |
| B | PHE849 |
| B | TRP872 |
| B | TYR902 |
| B | ILE904 |
| B | TRP951 |
| B | ASP953 |
| B | HOH3046 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NGW C 2041 |
| Chain | Residue |
| C | ARG641 |
| C | HIS742 |
| C | ASP804 |
| C | GLU805 |
| C | PHE849 |
| C | TRP872 |
| C | TYR902 |
| C | ILE904 |
| C | TRP951 |
| C | ASP953 |
| C | HOH3057 |
| C | HOH3547 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NGW D 2040 |
| Chain | Residue |
| D | ARG641 |
| D | HIS742 |
| D | ASP804 |
| D | GLU805 |
| D | PHE849 |
| D | TRP872 |
| D | TYR902 |
| D | TRP951 |
| D | ASP953 |
| D | HOH3054 |
| D | HOH3438 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 2042 |
| Chain | Residue |
| C | LYS642 |
| C | ASN710 |
| C | TYR959 |
| C | HOH3036 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 2043 |
| Chain | Residue |
| A | LYS642 |
| A | ASN710 |
| A | TYR959 |
| A | HOH3036 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 2045 |
| Chain | Residue |
| B | LYS642 |
| B | ASN710 |
| B | GLU958 |
| B | TYR959 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG A 2044 |
| Chain | Residue |
| A | VAL765 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 2043 |
| Chain | Residue |
| C | GLN823 |
| C | LEU824 |
| C | TYR825 |
| C | GLY826 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 2045 |
| Chain | Residue |
| A | THR897 |
| A | ASN898 |
| A | TYR902 |
| A | MET947 |
| A | LEU948 |
| A | SER949 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 2046 |
| Chain | Residue |
| A | TYR854 |
| A | GLN862 |
| A | LYS865 |
| A | LYS890 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 2044 |
| Chain | Residue |
| C | TYR854 |
| C | GLN862 |
| C | LYS865 |
| C | LYS890 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 2045 |
| Chain | Residue |
| A | TRP877 |
| C | LYS893 |
| C | HOH3255 |
| C | HOH3295 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 2046 |
| Chain | Residue |
| C | ALA760 |
| C | HIS761 |
| C | PHE762 |
| C | ASP771 |
| C | LEU824 |
| C | HOH3177 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 2047 |
| Chain | Residue |
| A | GLU658 |
| A | ASN982 |
| A | ASN984 |
| A | HOH3547 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO C 2047 |
| Chain | Residue |
| C | ALA837 |
| C | MET838 |
