Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AYK

CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH CGS-27023A, NMR, 30 STRUCTURES

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 170

Chain	Residue
A	HIS118
A	HIS122
A	HIS128
A	CGS173

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 171

Chain	Residue
A	VAL64
A	HIS68
A	HIS83
A	HIS96

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 172

Chain	Residue
A	GLY76
A	PRO77
A	GLY78
A	ASN80
A	ASP98
A	GLU101

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CGS A 173

Chain	Residue
A	ASN80
A	LEU81
A	ALA82
A	ARG114
A	HIS118
A	HIS122
A	HIS128
A	TYR137
A	PRO138
A	SER139
A	TYR140
A	ZN170

site_id	CAB
Number of Residues	3
Details	CA BINDING SITE.

Chain	Residue
A	GLY76
A	GLY78
A	ASN80

site_id	CGS
Number of Residues	12
Details	CGS-27023A BINDING SITE.

Chain	Residue
A	ASN80
A	LEU81
A	ALA82
A	HIS83
A	ARG114
A	VAL115
A	HIS118
A	GLU119
A	LEU135
A	PRO138
A	TYR137
A	SER139

site_id	ZNA
Number of Residues	3
Details	ZN BINDING SITE.

Chain	Residue
A	HIS118
A	HIS122
A	HIS128

site_id	ZNB
Number of Residues	3
Details	ZN BINDING SITE.

Chain	Residue
A	HIS68
A	HIS83
A	HIS96

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL

Chain	Residue	Details
A	VAL115-LEU124

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000105","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	MET136
A	GLU119

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	GLU119

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)