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4AY9

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005796cellular_componentGolgi lumen
A0006590biological_processthyroid hormone generation
A0007186biological_processG protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0008406biological_processgonad development
A0009755biological_processhormone-mediated signaling pathway
A0010469biological_processregulation of signaling receptor activity
A0010893biological_processpositive regulation of steroid biosynthetic process
A0016913molecular_functionfollicle-stimulating hormone activity
A0016914cellular_componentfollicle-stimulating hormone complex
A0030335biological_processpositive regulation of cell migration
A0030878biological_processthyroid gland development
A0032275biological_processluteinizing hormone secretion
A0032870biological_processcellular response to hormone stimulus
A0035265biological_processorgan growth
A0042699biological_processfollicle-stimulating hormone signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046621biological_processnegative regulation of organ growth
A0046884biological_processfollicle-stimulating hormone secretion
A0048589biological_processdevelopmental growth
A0061696cellular_componentpituitary gonadotropin complex
B0001541biological_processovarian follicle development
B0005179molecular_functionhormone activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0006701biological_processprogesterone biosynthetic process
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007186biological_processG protein-coupled receptor signaling pathway
B0007283biological_processspermatogenesis
B0007292biological_processfemale gamete generation
B0007565biological_processfemale pregnancy
B0008284biological_processpositive regulation of cell population proliferation
B0010469biological_processregulation of signaling receptor activity
B0010628biological_processpositive regulation of gene expression
B0010893biological_processpositive regulation of steroid biosynthetic process
B0016913molecular_functionfollicle-stimulating hormone activity
B0016914cellular_componentfollicle-stimulating hormone complex
B0030335biological_processpositive regulation of cell migration
B0042699biological_processfollicle-stimulating hormone signaling pathway
B0045670biological_processregulation of osteoclast differentiation
B0045780biological_processpositive regulation of bone resorption
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0060011biological_processSertoli cell proliferation
D0005179molecular_functionhormone activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005796cellular_componentGolgi lumen
D0006590biological_processthyroid hormone generation
D0007186biological_processG protein-coupled receptor signaling pathway
D0008284biological_processpositive regulation of cell population proliferation
D0008406biological_processgonad development
D0009755biological_processhormone-mediated signaling pathway
D0010469biological_processregulation of signaling receptor activity
D0010893biological_processpositive regulation of steroid biosynthetic process
D0016913molecular_functionfollicle-stimulating hormone activity
D0016914cellular_componentfollicle-stimulating hormone complex
D0030335biological_processpositive regulation of cell migration
D0030878biological_processthyroid gland development
D0032275biological_processluteinizing hormone secretion
D0032870biological_processcellular response to hormone stimulus
D0035265biological_processorgan growth
D0042699biological_processfollicle-stimulating hormone signaling pathway
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046621biological_processnegative regulation of organ growth
D0046884biological_processfollicle-stimulating hormone secretion
D0048589biological_processdevelopmental growth
D0061696cellular_componentpituitary gonadotropin complex
E0001541biological_processovarian follicle development
E0005179molecular_functionhormone activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005737cellular_componentcytoplasm
E0006701biological_processprogesterone biosynthetic process
E0007179biological_processtransforming growth factor beta receptor signaling pathway
E0007186biological_processG protein-coupled receptor signaling pathway
E0007283biological_processspermatogenesis
E0007292biological_processfemale gamete generation
E0007565biological_processfemale pregnancy
E0008284biological_processpositive regulation of cell population proliferation
E0010469biological_processregulation of signaling receptor activity
E0010628biological_processpositive regulation of gene expression
E0010893biological_processpositive regulation of steroid biosynthetic process
E0016913molecular_functionfollicle-stimulating hormone activity
E0016914cellular_componentfollicle-stimulating hormone complex
E0030335biological_processpositive regulation of cell migration
E0042699biological_processfollicle-stimulating hormone signaling pathway
E0045670biological_processregulation of osteoclast differentiation
E0045780biological_processpositive regulation of bone resorption
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0060011biological_processSertoli cell proliferation
G0005179molecular_functionhormone activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005796cellular_componentGolgi lumen
G0006590biological_processthyroid hormone generation
G0007186biological_processG protein-coupled receptor signaling pathway
G0008284biological_processpositive regulation of cell population proliferation
G0008406biological_processgonad development
G0009755biological_processhormone-mediated signaling pathway
G0010469biological_processregulation of signaling receptor activity
G0010893biological_processpositive regulation of steroid biosynthetic process
G0016913molecular_functionfollicle-stimulating hormone activity
G0016914cellular_componentfollicle-stimulating hormone complex
G0030335biological_processpositive regulation of cell migration
G0030878biological_processthyroid gland development
G0032275biological_processluteinizing hormone secretion
G0032870biological_processcellular response to hormone stimulus
G0035265biological_processorgan growth
G0042699biological_processfollicle-stimulating hormone signaling pathway
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0046621biological_processnegative regulation of organ growth
G0046884biological_processfollicle-stimulating hormone secretion
G0048589biological_processdevelopmental growth
G0061696cellular_componentpituitary gonadotropin complex
H0001541biological_processovarian follicle development
H0005179molecular_functionhormone activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005737cellular_componentcytoplasm
H0006701biological_processprogesterone biosynthetic process
H0007179biological_processtransforming growth factor beta receptor signaling pathway
H0007186biological_processG protein-coupled receptor signaling pathway
H0007283biological_processspermatogenesis
H0007292biological_processfemale gamete generation
H0007565biological_processfemale pregnancy
H0008284biological_processpositive regulation of cell population proliferation
H0010469biological_processregulation of signaling receptor activity
H0010628biological_processpositive regulation of gene expression
H0010893biological_processpositive regulation of steroid biosynthetic process
H0016913molecular_functionfollicle-stimulating hormone activity
H0016914cellular_componentfollicle-stimulating hormone complex
H0030335biological_processpositive regulation of cell migration
H0042699biological_processfollicle-stimulating hormone signaling pathway
H0045670biological_processregulation of osteoclast differentiation
H0045780biological_processpositive regulation of bone resorption
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0060011biological_processSertoli cell proliferation
X0004963molecular_functionfollicle-stimulating hormone receptor activity
X0007186biological_processG protein-coupled receptor signaling pathway
X0016020cellular_componentmembrane
Y0004963molecular_functionfollicle-stimulating hormone receptor activity
Y0007186biological_processG protein-coupled receptor signaling pathway
Y0016020cellular_componentmembrane
Z0004963molecular_functionfollicle-stimulating hormone receptor activity
Z0007186biological_processG protein-coupled receptor signaling pathway
Z0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00261
Number of Residues7
DetailsGLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCyT
ChainResidueDetails
BCYS28-THR34

site_idPS00689
Number of Residues28
DetailsGLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. PVAtqChCgkCdsdsTDCtvrglg..PsyC
ChainResidueDetails
BPRO77-CYS104

site_idPS00779
Number of Residues13
DetailsGLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP
ChainResidueDetails
ACYS28-PRO40

site_idPS00780
Number of Residues14
DetailsGLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK
ChainResidueDetails
AASN78-LYS91

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15662415, ECO:0000269|PubMed:24692546, ECO:0007744|PDB:4MQW
ChainResidueDetails
AASN52
AASN78
DASN52
DASN78
GASN52
GASN78

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: Sulfotyrosine => ECO:0000305|PubMed:11847099
ChainResidueDetails
XTYS335
YTYS335
ZTYS335

site_idSWS_FT_FI3
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15662415, ECO:0000269|PubMed:24692546, ECO:0007744|PDB:4MQW
ChainResidueDetails
XASN191
YASN191
ZASN191

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
XASN199
XASN318
YASN199
YASN318
ZASN199
ZASN318

site_idSWS_FT_FI5
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250
ChainResidueDetails
XASN293
YASN293
ZASN293

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PDB entries from 2024-10-30

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