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4AWN

Structure of recombinant human DNase I (rhDNaseI) in complex with Magnesium and Phosphate.

Functional Information from GO Data
ChainGOidnamespacecontents
A0002283biological_processneutrophil activation involved in immune response
A0002673biological_processregulation of acute inflammatory response
A0003677molecular_functionDNA binding
A0003779molecular_functionactin binding
A0003824molecular_functioncatalytic activity
A0004519molecular_functionendonuclease activity
A0004530molecular_functiondeoxyribonuclease I activity
A0004536molecular_functionDNA nuclease activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0006308biological_processDNA catabolic process
A0006915biological_processapoptotic process
A0031410cellular_componentcytoplasmic vesicle
A0042588cellular_componentzymogen granule
A0070062cellular_componentextracellular exosome
A0070948biological_processregulation of neutrophil mediated cytotoxicity
Functional Information from PROSITE/UniProt
site_idPS00918
Number of Residues8
DetailsDNASE_I_2 Deoxyribonuclease I signature 2. GDFNAgCS
ChainResidueDetails
AGLY167-SER174

site_idPS00919
Number of Residues21
DetailsDNASE_I_1 Deoxyribonuclease I signature 1. IVPLHAAPgdavaEIDaLyDV
ChainResidueDetails
AILE130-VAL150

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P00639
ChainResidueDetails
AGLU78
AHIS134

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Involved in actin-binding => ECO:0000250|UniProtKB:P00639
ChainResidueDetails
AGLU13
AVAL67

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Nitration by tetranitromethane destroys a Ca(2+) binding site and inactivates enzyme => ECO:0000250|UniProtKB:P00639
ChainResidueDetails
ATYR65

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2277032
ChainResidueDetails
AASN18

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN106

223532

PDB entries from 2024-08-07

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