4AVP

Crystal structure of the DNA-binding domain of human ETV1.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0043565	molecular_function	sequence-specific DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 1427

Chain	Residue
B	ARG381
B	ALA383
B	LYS388
B	HOH2037
D	LYS364
D	ILE366

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 1427

Chain	Residue
B	PRO348
D	SER334
D	LYS379

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Functional Information from PROSITE/UniProt

site_id	PS00345
Number of Residues	9
Details	ETS_DOMAIN_1 Ets-domain signature 1. LWQFLVALL

Chain	Residue	Details
A	LEU337-LEU345

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site_id	PS00346
Number of Residues	16
Details	ETS_DOMAIN_2 Ets-domain signature 2. RpaMnYDkLSRSLRyY

Chain	Residue	Details
A	ARG381-TYR396

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	DNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237

Chain	Residue	Details
A	LEU335-VAL415
B	LEU335-VAL415
C	LEU335-VAL415
D	LEU335-VAL415

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