Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AU5

Structure of the NhaA dimer, crystallised at low pH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006885	biological_process	regulation of pH
A	0009651	biological_process	response to salt stress
A	0010446	biological_process	response to alkaline pH
A	0015081	molecular_function	sodium ion transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015385	molecular_function	sodium:proton antiporter activity
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0051453	biological_process	regulation of intracellular pH
A	0055085	biological_process	transmembrane transport
A	1901612	molecular_function	cardiolipin binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0006885	biological_process	regulation of pH
B	0009651	biological_process	response to salt stress
B	0010446	biological_process	response to alkaline pH
B	0015081	molecular_function	sodium ion transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015385	molecular_function	sodium:proton antiporter activity
B	0016020	cellular_component	membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0051453	biological_process	regulation of intracellular pH
B	0055085	biological_process	transmembrane transport
B	1901612	molecular_function	cardiolipin binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0006885	biological_process	regulation of pH
C	0009651	biological_process	response to salt stress
C	0010446	biological_process	response to alkaline pH
C	0015081	molecular_function	sodium ion transmembrane transporter activity
C	0015297	molecular_function	antiporter activity
C	0015385	molecular_function	sodium:proton antiporter activity
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0051453	biological_process	regulation of intracellular pH
C	0055085	biological_process	transmembrane transport
C	1901612	molecular_function	cardiolipin binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0006885	biological_process	regulation of pH
D	0009651	biological_process	response to salt stress
D	0010446	biological_process	response to alkaline pH
D	0015081	molecular_function	sodium ion transmembrane transporter activity
D	0015297	molecular_function	antiporter activity
D	0015385	molecular_function	sodium:proton antiporter activity
D	0016020	cellular_component	membrane
D	0035725	biological_process	sodium ion transmembrane transport
D	0051453	biological_process	regulation of intracellular pH
D	0055085	biological_process	transmembrane transport
D	1901612	molecular_function	cardiolipin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMU B 1384

Chain	Residue
A	THR205
B	ARG250
B	TRP258
B	SO41385

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1385

Chain	Residue
B	LMU1384
A	ARG204
A	THR205
A	GLY206
B	VAL254
B	TRP258

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1386

Chain	Residue
B	ARG204
B	THR205
B	GLY206

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1391

Chain	Residue
C	ARG204
C	THR205
C	GLY206
D	VAL254

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1384

Chain	Residue
C	VAL254
D	ARG204
D	THR205
D	GLY206

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	216
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	340
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	92
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	14
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	52
Details	Region: {"description":"Important for dimerization","evidences":[{"source":"PubMed","id":"17635927","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23836890","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Site: {"description":"Important for stability, cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29410365","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Site: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Site: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	8
Details	Site: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"10455127","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	4
Details	Site: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"14604993","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Site: {"description":"Important for stability and activity","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28330875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)