4ATB

Crystal structure of the NF90-NF45 dimerisation domain complex with CTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003725	molecular_function	double-stranded RNA binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	1990904	cellular_component	ribonucleoprotein complex
C	0003677	molecular_function	DNA binding
C	0003725	molecular_function	double-stranded RNA binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CTP C 1362

Chain	Residue
C	GLY106
C	SER107
C	LYS110
C	ASP121
C	SER200
C	ALA204
C	HIS207
C	LYS228
C	MG1363

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1362

Chain	Residue
A	SER107
A	VAL119
A	ASP121
A	CTP1363

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CTP A 1363

Chain	Residue
A	GLY106
A	SER107
A	LYS110
A	ASP121
A	SER200
A	ALA204
A	HIS207
A	LYS228
A	MG1362

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 1363

Chain	Residue
C	SER107
C	VAL119
C	ASP121
C	CTP1362

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
B	THR67
D	THR67
C	SER52
C	SER68

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q12906

Chain	Residue	Details
B	LYS100
D	LYS100

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKR => ECO:0000269|PubMed:21123651

Chain	Residue	Details
B	THR188
B	THR315
D	THR188
D	THR315

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
B	SER190
D	SER190
A	LYS364
C	LYS186
C	LYS364

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q12906

Chain	Residue	Details
B	LYS297
D	LYS297

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000250|UniProtKB:Q12906

Chain	Residue	Details
B	LYS348
D	LYS348

---