4AP4

Rnf4 - ubch5a - ubiquitin heterotrimeric complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000151	cellular_component	ubiquitin ligase complex
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0019787	molecular_function	ubiquitin-like protein transferase activity
B	0030514	biological_process	negative regulation of BMP signaling pathway
B	0031398	biological_process	positive regulation of protein ubiquitination
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032991	cellular_component	protein-containing complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070936	biological_process	protein K48-linked ubiquitination
B	1902916	biological_process	positive regulation of protein polyubiquitination
B	1904262	biological_process	negative regulation of TORC1 signaling
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000151	cellular_component	ubiquitin ligase complex
E	0000166	molecular_function	nucleotide binding
E	0000209	biological_process	protein polyubiquitination
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0019787	molecular_function	ubiquitin-like protein transferase activity
E	0030514	biological_process	negative regulation of BMP signaling pathway
E	0031398	biological_process	positive regulation of protein ubiquitination
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032991	cellular_component	protein-containing complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0061631	molecular_function	ubiquitin conjugating enzyme activity
E	0070936	biological_process	protein K48-linked ubiquitination
E	1902916	biological_process	positive regulation of protein polyubiquitination
E	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 800

Chain	Residue
A	CYS136
A	CYS139
A	CYS163
A	CYS166

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 801

Chain	Residue
A	CYS158
A	HIS160
A	CYS177
A	CYS180

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 802

Chain	Residue
A	CYS204
A	CYS228
A	CYS231
A	CYS201

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 803

Chain	Residue
A	CYS223
A	HIS225
A	CYS242
A	CYS245

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Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHvFCsqCL

Chain	Residue	Details
A	CYS158-LEU167
A	CYS223-LEU232

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site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
C	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133

Chain	Residue	Details
B	LYS85
E	LYS85

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:20681948, ECO:0007744|PDB:3NG2

Chain	Residue	Details
A	CYS201
A	CYS204
A	CYS223
A	HIS225
A	CYS228
A	CYS231
A	CYS242
A	CYS245

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