4AM8
Crystal structure of the R54G mutant of putrescine transcarbamylase from Enterococcus faecalis bound to a curing guanidinium ion
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| A | 0033390 | biological_process | putrescine biosynthetic process from arginine via N-carbamoylputrescine |
| A | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| A | 0050231 | molecular_function | putrescine carbamoyltransferase activity |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| B | 0033390 | biological_process | putrescine biosynthetic process from arginine via N-carbamoylputrescine |
| B | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| B | 0050231 | molecular_function | putrescine carbamoyltransferase activity |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| C | 0033390 | biological_process | putrescine biosynthetic process from arginine via N-carbamoylputrescine |
| C | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| C | 0050231 | molecular_function | putrescine carbamoyltransferase activity |
| D | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006591 | biological_process | ornithine metabolic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0019240 | biological_process | citrulline biosynthetic process |
| D | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| D | 0033390 | biological_process | putrescine biosynthetic process from arginine via N-carbamoylputrescine |
| D | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| D | 0050231 | molecular_function | putrescine carbamoyltransferase activity |
| E | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0006591 | biological_process | ornithine metabolic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0019240 | biological_process | citrulline biosynthetic process |
| E | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| E | 0033390 | biological_process | putrescine biosynthetic process from arginine via N-carbamoylputrescine |
| E | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| E | 0050231 | molecular_function | putrescine carbamoyltransferase activity |
| F | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0006591 | biological_process | ornithine metabolic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0019240 | biological_process | citrulline biosynthetic process |
| F | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| F | 0033390 | biological_process | putrescine biosynthetic process from arginine via N-carbamoylputrescine |
| F | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| F | 0050231 | molecular_function | putrescine carbamoyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PAO A 1338 |
| Chain | Residue |
| A | SER52 |
| A | LEU270 |
| A | ARG297 |
| A | GAI403 |
| A | HOH524 |
| A | HOH550 |
| A | HOH626 |
| A | HOH590 |
| A | HOH509 |
| A | HOH583 |
| A | THR53 |
| A | GLY54 |
| A | THR55 |
| A | ARG103 |
| A | HIS130 |
| A | THR163 |
| A | GLN164 |
| A | ASP227 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI A 1339 |
| Chain | Residue |
| A | GLN50 |
| A | SER51 |
| A | ARG103 |
| A | MET125 |
| A | PAO402 |
| A | HOH509 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TRS A 1340 |
| Chain | Residue |
| A | ASP161 |
| A | ALA162 |
| A | PHE188 |
| A | HOH555 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NI A 1341 |
| Chain | Residue |
| A | HIS69 |
| A | HOH563 |
| C | HOH540 |
| B | HIS69 |
| B | HOH531 |
| C | HIS69 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PAO B 1340 |
| Chain | Residue |
| B | SER52 |
| B | THR53 |
| B | GLY54 |
| B | THR55 |
| B | ARG103 |
| B | HIS130 |
| B | THR163 |
| B | GLN164 |
| B | ASP227 |
| B | LEU270 |
| B | ARG297 |
| B | GAI403 |
| B | HOH598 |
| B | HOH555 |
| B | HOH553 |
| B | HOH622 |
| B | HOH605 |
| B | HOH570 |
| B | HOH518 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GAI B 1341 |
| Chain | Residue |
| B | GLN50 |
| B | SER51 |
| B | ARG103 |
| B | MET125 |
| B | TYR233 |
| B | PAO402 |
| B | HOH605 |
| B | HOH518 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TRS B 1342 |
| Chain | Residue |
| B | ASP161 |
| B | ALA162 |
| B | PHE188 |
| B | GLY231 |
| B | LEU232 |
| B | HOH544 |
| B | HOH504 |
| B | HOH502 |
| B | HOH558 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PAO C 1338 |
| Chain | Residue |
| C | SER52 |
| C | THR53 |
| C | GLY54 |
| C | THR55 |
| C | ARG103 |
| C | HIS130 |
| C | GLN164 |
| C | ASP227 |
| C | LEU270 |
| C | ARG297 |
| C | GAI403 |
| C | HOH606 |
| C | HOH539 |
| C | HOH619 |
| C | HOH591 |
| C | HOH615 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI C 1339 |
| Chain | Residue |
| C | GLN50 |
| C | SER51 |
| C | ARG103 |
| C | MET125 |
| C | TYR233 |
| C | PAO402 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TRS C 1340 |
| Chain | Residue |
| C | ASP161 |
| C | ALA162 |
| C | GLY231 |
| C | HOH521 |
| C | HOH575 |
| site_id | BC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PAO D 1350 |
| Chain | Residue |
| D | GLY54 |
| D | THR55 |
| D | ARG103 |
| D | HIS130 |
| D | THR163 |
| D | GLN164 |
| D | VAL165 |
| D | ASP227 |
| D | LEU270 |
| D | ARG297 |
| D | GAI402 |
| D | HOH513 |
| D | HOH640 |
| D | HOH600 |
| D | HOH561 |
| D | HOH569 |
| D | SER52 |
| D | THR53 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI D 1351 |
| Chain | Residue |
| D | GLN50 |
| D | SER51 |
| D | ARG103 |
| D | MET125 |
| D | PAO401 |
| D | HOH569 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NI D 1352 |
| Chain | Residue |
| D | HIS69 |
| D | HOH510 |
| F | HOH537 |
| E | HIS69 |
| E | HOH543 |
| F | HIS69 |
| site_id | BC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PAO E 1338 |
| Chain | Residue |
| E | SER52 |
| E | THR53 |
| E | GLY54 |
| E | THR55 |
| E | ARG103 |
| E | HIS130 |
| E | GLN164 |
| E | ASP227 |
| E | LEU270 |
| E | ARG297 |
| E | GAI403 |
| E | HOH563 |
| E | HOH548 |
| E | HOH541 |
| E | HOH561 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI E 1339 |
| Chain | Residue |
| E | GLN50 |
| E | SER51 |
| E | ARG103 |
| E | MET125 |
| E | TYR233 |
| E | PAO402 |
| site_id | BC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PAO F 1337 |
| Chain | Residue |
| F | SER52 |
| F | THR53 |
| F | GLY54 |
| F | THR55 |
| F | ARG103 |
| F | HIS130 |
| F | GLN164 |
| F | VAL165 |
| F | ASP227 |
| F | LEU270 |
| F | ARG297 |
| D | GAI403 |
| F | GAI403 |
| F | HOH556 |
| F | HOH583 |
| F | HOH544 |
| F | HOH577 |
| F | HOH511 |
| D | HOH555 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GAI F 1338 |
| Chain | Residue |
| D | GLU84 |
| D | VAL92 |
| F | GLY54 |
| F | PRO271 |
| F | PAO402 |
| D | HOH614 |
| D | HOH555 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GAI F 1339 |
| Chain | Residue |
| F | GLN50 |
| F | SER51 |
| F | ARG103 |
| F | MET125 |
| F | TYR233 |
| F | PAO402 |
| F | HOH577 |
| F | HOH511 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TRS F 1340 |
| Chain | Residue |
| F | ASP161 |
| F | ALA162 |
| F | PHE188 |
| F | LEU232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Site: {"description":"Important for structural integrity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
