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4AIG

ADAMALYSIN II WITH PHOSPHONATE INHIBITOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 999
ChainResidue
AHIS142
AHIS146
AHIS152
AFLX400

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 250
ChainResidue
AHOH504
AGLU9
AASP93
AGLN196
ACYS197
AASN200

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE FLX A 400
ChainResidue
AGLY105
ALYS106
AILE107
AILE108
AGLY109
AHIS142
AGLU143
AHIS146
AHIS152
AILE165
AARG167
APRO168
AGLY169
ALEU170
AHOH503
AHOH512
AHOH615
AHOH617
AZN999

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMAHELGHNL
ChainResidueDetails
ATHR139-LEU148

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095
ChainResidueDetails
AGLU143

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:9521103
ChainResidueDetails
AGLU9
AASP93
ACYS197
AASN200

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING:
ChainResidueDetails
AHIS142
AHIS146
AHIS152

227561

PDB entries from 2024-11-20

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