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4AF8

The structural basis for metacaspase substrate specificity and activation

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
A0046872molecular_functionmetal ion binding
A0055037cellular_componentrecycling endosome
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA A 1348
ChainResidue
ALEU23
AGLN98
AHOH2115
AHOH2240

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE NA A 1349
ChainResidue
AGLN29
ALYS314
AARG315

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE NA A 1350
ChainResidue
AHOH2170
ASER198
AASP247

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL A 1351
ChainResidue
ALYS163
AHIS238
AASP329
AHOH2214
AHOH2276
AHOH2288

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA A 1352
ChainResidue
AGLN34
ALEU36
AHIS158
AGLY159
AHOH2149

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 1353
ChainResidue
ALEU68
AGLN71
AHOH2122

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q08601
ChainResidueDetails
AHIS158

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:18005666
ChainResidueDetails
AGLY213

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:22529389, ECO:0007744|PDB:4AFP
ChainResidueDetails
AASP190
AASP220
AASP173
AASP189

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:18005666
ChainResidueDetails
ALYS55
ALYS268

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Important for Arg/Lys-specific substrate specificity => ECO:0000269|PubMed:22529389
ChainResidueDetails
AASP95
AASP211

221051

PDB entries from 2024-06-12

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