4AF8

The structural basis for metacaspase substrate specificity and activation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0055037	cellular_component	recycling endosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 1348

Chain	Residue
A	LEU23
A	GLN98
A	HOH2115
A	HOH2240

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1349

Chain	Residue
A	GLN29
A	LYS314
A	ARG315

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1350

Chain	Residue
A	HOH2170
A	SER198
A	ASP247

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 1351

Chain	Residue
A	LYS163
A	HIS238
A	ASP329
A	HOH2214
A	HOH2276
A	HOH2288

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1352

Chain	Residue
A	GLN34
A	LEU36
A	HIS158
A	GLY159
A	HOH2149

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1353

Chain	Residue
A	LEU68
A	GLN71
A	HOH2122

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q08601","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"18005666","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22529389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"18005666","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important for Arg/Lys-specific substrate specificity","evidences":[{"source":"PubMed","id":"22529389","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---