4AEZ

Crystal Structure of Mitotic Checkpoint Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0010997	molecular_function	anaphase-promoting complex binding
A	0097027	molecular_function	ubiquitin-protein transferase activator activity
A	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
B	0000776	cellular_component	kinetochore
B	0000785	cellular_component	chromatin
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0007094	biological_process	mitotic spindle assembly checkpoint signaling
B	0010997	molecular_function	anaphase-promoting complex binding
B	0033316	biological_process	meiotic spindle assembly checkpoint signaling
B	0033597	cellular_component	mitotic checkpoint complex
B	0034399	cellular_component	nuclear periphery
B	0044732	cellular_component	mitotic spindle pole body
B	0045841	biological_process	negative regulation of mitotic metaphase/anaphase transition
B	0051301	biological_process	cell division
B	0140678	molecular_function	molecular function inhibitor activity
B	1905318	biological_process	meiosis I spindle assembly checkpoint signaling
B	1990498	cellular_component	mitotic spindle microtubule
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
D	0010997	molecular_function	anaphase-promoting complex binding
D	0097027	molecular_function	ubiquitin-protein transferase activator activity
D	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
E	0000776	cellular_component	kinetochore
E	0000785	cellular_component	chromatin
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0007094	biological_process	mitotic spindle assembly checkpoint signaling
E	0010997	molecular_function	anaphase-promoting complex binding
E	0033316	biological_process	meiotic spindle assembly checkpoint signaling
E	0033597	cellular_component	mitotic checkpoint complex
E	0034399	cellular_component	nuclear periphery
E	0044732	cellular_component	mitotic spindle pole body
E	0045841	biological_process	negative regulation of mitotic metaphase/anaphase transition
E	0051301	biological_process	cell division
E	0140678	molecular_function	molecular function inhibitor activity
E	1905318	biological_process	meiosis I spindle assembly checkpoint signaling
E	1990498	cellular_component	mitotic spindle microtubule
F	0007094	biological_process	mitotic spindle assembly checkpoint signaling
G	0010997	molecular_function	anaphase-promoting complex binding
G	0097027	molecular_function	ubiquitin-protein transferase activator activity
G	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
H	0000776	cellular_component	kinetochore
H	0000785	cellular_component	chromatin
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0007094	biological_process	mitotic spindle assembly checkpoint signaling
H	0010997	molecular_function	anaphase-promoting complex binding
H	0033316	biological_process	meiotic spindle assembly checkpoint signaling
H	0033597	cellular_component	mitotic checkpoint complex
H	0034399	cellular_component	nuclear periphery
H	0044732	cellular_component	mitotic spindle pole body
H	0045841	biological_process	negative regulation of mitotic metaphase/anaphase transition
H	0051301	biological_process	cell division
H	0140678	molecular_function	molecular function inhibitor activity
H	1905318	biological_process	meiosis I spindle assembly checkpoint signaling
H	1990498	cellular_component	mitotic spindle microtubule
I	0007094	biological_process	mitotic spindle assembly checkpoint signaling

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASGgnDnVVQIWDA

Chain	Residue	Details
A	LEU319-ALA333
A	THR364-ALA378

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	111
Details	Repeat: {"description":"WD 1"}

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site_id	SWS_FT_FI2
Number of Residues	117
Details	Repeat: {"description":"WD 2"}

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site_id	SWS_FT_FI3
Number of Residues	111
Details	Repeat: {"description":"WD 3"}

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site_id	SWS_FT_FI4
Number of Residues	117
Details	Repeat: {"description":"WD 4"}

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site_id	SWS_FT_FI5
Number of Residues	126
Details	Repeat: {"description":"WD 5"}

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site_id	SWS_FT_FI6
Number of Residues	123
Details	Repeat: {"description":"WD 6"}

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site_id	SWS_FT_FI7
Number of Residues	162
Details	Domain: {"description":"BUB1 N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00822","evidenceCode":"ECO:0000255"}]}

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Residue

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site_id	SWS_FT_FI8
Number of Residues	129
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

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Residue

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site_id	SWS_FT_FI9
Number of Residues	63
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

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