4AEA

Dimeric alpha-cobratoxin X-ray structure: Localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0030550	molecular_function	acetylcholine receptor inhibitor activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity
B	0005576	cellular_component	extracellular region
B	0030550	molecular_function	acetylcholine receptor inhibitor activity
B	0035821	biological_process	modulation of process of another organism
B	0090729	molecular_function	toxin activity
B	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD A 100

Chain	Residue
A	PHE4
A	PRO64
A	PHE65
B	THR50

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GLY A 1068

Chain	Residue
A	ILE5

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Functional Information from PROSITE/UniProt

site_id	PS00272
Number of Residues	21
Details	SNAKE_TOXIN Snake toxins signature. GCaatCPtvktgvdiq.CCstD

Chain	Residue	Details
A	GLY40-ASP60

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Binds to Torpedo AChR => ECO:0000269|PubMed:10574958

Chain	Residue	Details
A	LYS23
A	LYS49
B	LYS23
B	LYS49

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site_id	SWS_FT_FI2
Number of Residues	10
Details	SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927

Chain	Residue	Details
A	TRP25
A	ASP27
A	PHE29
A	ARG33
A	PHE65
B	TRP25
B	ASP27
B	PHE29
B	ARG33
B	PHE65

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Binds to alpha-7/CHRNA7 AChR => ECO:0000269|PubMed:10852927

Chain	Residue	Details
A	ALA28
A	LYS35
B	ALA28
B	LYS35

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs, may be important for inhibition of GABA(A) receptors => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927, ECO:0000305|PubMed:26221036

Chain	Residue	Details
A	ARG36
B	ARG36

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