4AE1

Crystal structure of diphtheria toxin mutant CRM197 in complex with nicotinamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0008320	molecular_function	protein transmembrane transporter activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0035821	biological_process	modulation of process of another organism
A	0042802	molecular_function	identical protein binding
A	0047286	molecular_function	NAD+-diphthamide ADP-ribosyltransferase activity
A	0071806	biological_process	protein transmembrane transport
A	0090729	molecular_function	toxin activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0008320	molecular_function	protein transmembrane transporter activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0035821	biological_process	modulation of process of another organism
B	0042802	molecular_function	identical protein binding
B	0047286	molecular_function	NAD+-diphthamide ADP-ribosyltransferase activity
B	0071806	biological_process	protein transmembrane transport
B	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NCA B 1536

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NCA A 1536

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Modification inactivates enzyme

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cleavage; by furin => ECO:0000269\|PubMed:8253774

Catalytic Information from CSA

Chain	Residue	Details
A	GLU148	electrostatic stabiliser

Chain	Residue	Details
B	GLU148	electrostatic stabiliser