4ADL
Crystal structures of Rv1098c in complex with malate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004333 | molecular_function | fumarate hydratase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006106 | biological_process | fumarate metabolic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016829 | molecular_function | lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004333 | molecular_function | fumarate hydratase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006106 | biological_process | fumarate metabolic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016829 | molecular_function | lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004333 | molecular_function | fumarate hydratase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006106 | biological_process | fumarate metabolic process |
| C | 0009274 | cellular_component | peptidoglycan-based cell wall |
| C | 0016829 | molecular_function | lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004333 | molecular_function | fumarate hydratase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006106 | biological_process | fumarate metabolic process |
| D | 0009274 | cellular_component | peptidoglycan-based cell wall |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE LMR C 1468 |
| Chain | Residue |
| A | SER104 |
| C | SER319 |
| C | ILE320 |
| C | MET321 |
| C | LYS324 |
| C | ASN326 |
| A | THR106 |
| A | SER138 |
| A | SER139 |
| A | ASN140 |
| B | THR186 |
| B | HIS187 |
| C | GLY317 |
| C | SER318 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE LMR D 1468 |
| Chain | Residue |
| A | THR186 |
| A | HIS187 |
| B | SER104 |
| B | THR106 |
| B | SER138 |
| B | SER139 |
| B | ASN140 |
| D | GLY317 |
| D | SER318 |
| D | SER319 |
| D | ILE320 |
| D | MET321 |
| D | LYS324 |
| D | ASN326 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSsiMpGKvN |
| Chain | Residue | Details |
| A | GLY317-ASN326 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305|PubMed:22561013, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4ADM |
| Chain | Residue | Details |
| A | HIS187 | |
| B | HIS187 | |
| C | HIS187 | |
| D | HIS187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0007744|PDB:4ADM |
| Chain | Residue | Details |
| A | SER318 | |
| B | SER318 | |
| C | SER318 | |
| D | SER318 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4ADM, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F92 |
| Chain | Residue | Details |
| A | SER104 | |
| B | SER104 | |
| C | SER104 | |
| D | SER104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: in site B => ECO:0000255|HAMAP-Rule:MF_00743 |
| Chain | Residue | Details |
| A | HIS128 | |
| B | HIS128 | |
| C | HIS128 | |
| D | HIS128 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4ADM, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F91, ECO:0007744|PDB:5F92 |
| Chain | Residue | Details |
| C | SER138 | |
| C | LYS324 | |
| D | SER138 | |
| D | LYS324 | |
| A | SER138 | |
| A | LYS324 | |
| B | SER138 | |
| B | LYS324 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F91, ECO:0007744|PDB:5F92 |
| Chain | Residue | Details |
| A | THR186 | |
| B | THR186 | |
| C | THR186 | |
| D | THR186 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F92 |
| Chain | Residue | Details |
| A | SER319 | |
| B | SER319 | |
| C | SER319 | |
| D | SER319 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_00743 |
| Chain | Residue | Details |
| A | GLU331 | |
| B | GLU331 | |
| C | GLU331 | |
| D | GLU331 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
