Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AB3

ATP-triggered molecular mechanics of the chaperonin GroEL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0009314	biological_process	response to radiation
A	0009408	biological_process	response to heat
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0019068	biological_process	virion assembly
A	0042026	biological_process	protein refolding
A	0042802	molecular_function	identical protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
A	1990220	cellular_component	GroEL-GroES complex
B	0000287	molecular_function	magnesium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006457	biological_process	protein folding
B	0009314	biological_process	response to radiation
B	0009408	biological_process	response to heat
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0019068	biological_process	virion assembly
B	0042026	biological_process	protein refolding
B	0042802	molecular_function	identical protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone
B	1990220	cellular_component	GroEL-GroES complex
C	0000287	molecular_function	magnesium ion binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0009314	biological_process	response to radiation
C	0009408	biological_process	response to heat
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0019068	biological_process	virion assembly
C	0042026	biological_process	protein refolding
C	0042802	molecular_function	identical protein binding
C	0140662	molecular_function	ATP-dependent protein folding chaperone
C	1990220	cellular_component	GroEL-GroES complex
D	0000287	molecular_function	magnesium ion binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006457	biological_process	protein folding
D	0009314	biological_process	response to radiation
D	0009408	biological_process	response to heat
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0019068	biological_process	virion assembly
D	0042026	biological_process	protein refolding
D	0042802	molecular_function	identical protein binding
D	0140662	molecular_function	ATP-dependent protein folding chaperone
D	1990220	cellular_component	GroEL-GroES complex
E	0000287	molecular_function	magnesium ion binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006457	biological_process	protein folding
E	0009314	biological_process	response to radiation
E	0009408	biological_process	response to heat
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0019068	biological_process	virion assembly
E	0042026	biological_process	protein refolding
E	0042802	molecular_function	identical protein binding
E	0140662	molecular_function	ATP-dependent protein folding chaperone
E	1990220	cellular_component	GroEL-GroES complex
F	0000287	molecular_function	magnesium ion binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006457	biological_process	protein folding
F	0009314	biological_process	response to radiation
F	0009408	biological_process	response to heat
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0019068	biological_process	virion assembly
F	0042026	biological_process	protein refolding
F	0042802	molecular_function	identical protein binding
F	0140662	molecular_function	ATP-dependent protein folding chaperone
F	1990220	cellular_component	GroEL-GroES complex
G	0000287	molecular_function	magnesium ion binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0009314	biological_process	response to radiation
G	0009408	biological_process	response to heat
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0019068	biological_process	virion assembly
G	0042026	biological_process	protein refolding
G	0042802	molecular_function	identical protein binding
G	0140662	molecular_function	ATP-dependent protein folding chaperone
G	1990220	cellular_component	GroEL-GroES complex
H	0000287	molecular_function	magnesium ion binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006457	biological_process	protein folding
H	0009314	biological_process	response to radiation
H	0009408	biological_process	response to heat
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0019068	biological_process	virion assembly
H	0042026	biological_process	protein refolding
H	0042802	molecular_function	identical protein binding
H	0140662	molecular_function	ATP-dependent protein folding chaperone
H	1990220	cellular_component	GroEL-GroES complex
I	0000287	molecular_function	magnesium ion binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006457	biological_process	protein folding
I	0009314	biological_process	response to radiation
I	0009408	biological_process	response to heat
I	0016020	cellular_component	membrane
I	0016887	molecular_function	ATP hydrolysis activity
I	0019068	biological_process	virion assembly
I	0042026	biological_process	protein refolding
I	0042802	molecular_function	identical protein binding
I	0140662	molecular_function	ATP-dependent protein folding chaperone
I	1990220	cellular_component	GroEL-GroES complex
J	0000287	molecular_function	magnesium ion binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006457	biological_process	protein folding
J	0009314	biological_process	response to radiation
J	0009408	biological_process	response to heat
J	0016020	cellular_component	membrane
J	0016887	molecular_function	ATP hydrolysis activity
J	0019068	biological_process	virion assembly
J	0042026	biological_process	protein refolding
J	0042802	molecular_function	identical protein binding
J	0140662	molecular_function	ATP-dependent protein folding chaperone
J	1990220	cellular_component	GroEL-GroES complex
K	0000287	molecular_function	magnesium ion binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006457	biological_process	protein folding
K	0009314	biological_process	response to radiation
K	0009408	biological_process	response to heat
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0019068	biological_process	virion assembly
K	0042026	biological_process	protein refolding
K	0042802	molecular_function	identical protein binding
K	0140662	molecular_function	ATP-dependent protein folding chaperone
K	1990220	cellular_component	GroEL-GroES complex
L	0000287	molecular_function	magnesium ion binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006457	biological_process	protein folding
L	0009314	biological_process	response to radiation
L	0009408	biological_process	response to heat
L	0016020	cellular_component	membrane
L	0016887	molecular_function	ATP hydrolysis activity
L	0019068	biological_process	virion assembly
L	0042026	biological_process	protein refolding
L	0042802	molecular_function	identical protein binding
L	0140662	molecular_function	ATP-dependent protein folding chaperone
L	1990220	cellular_component	GroEL-GroES complex
M	0000287	molecular_function	magnesium ion binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006457	biological_process	protein folding
M	0009314	biological_process	response to radiation
M	0009408	biological_process	response to heat
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0019068	biological_process	virion assembly
M	0042026	biological_process	protein refolding
M	0042802	molecular_function	identical protein binding
M	0140662	molecular_function	ATP-dependent protein folding chaperone
M	1990220	cellular_component	GroEL-GroES complex
N	0000287	molecular_function	magnesium ion binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006457	biological_process	protein folding
N	0009314	biological_process	response to radiation
N	0009408	biological_process	response to heat
N	0016020	cellular_component	membrane
N	0016887	molecular_function	ATP hydrolysis activity
N	0019068	biological_process	virion assembly
N	0042026	biological_process	protein refolding
N	0042802	molecular_function	identical protein binding
N	0140662	molecular_function	ATP-dependent protein folding chaperone
N	1990220	cellular_component	GroEL-GroES complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 1525

Chain	Residue
A	LYS51
A	ASP52
A	ATP1527

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1526

Chain	Residue
A	ASP87
A	GLY88
A	SER151
A	ATP1527

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP A 1527

Chain	Residue
A	ASP87
A	GLY88
A	THR89
A	THR90
A	THR91
A	ILE150
A	ASN153
A	GLY414
A	GLY415
A	ILE454
A	ASP495
A	PO41525
A	MG1526
A	LEU31
A	GLY53

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 B 1525

Chain	Residue
B	LYS51
B	ASP52
B	ATP1527

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 1526

Chain	Residue
B	ASP87
B	GLY88
B	SER151
B	ATP1527

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP B 1527

Chain	Residue
B	LEU31
B	GLY53
B	ASP87
B	GLY88
B	THR89
B	THR90
B	THR91
B	ILE150
B	SER151
B	ASN153
B	GLY414
B	GLY415
B	ILE454
B	ASP495
B	PO41525
B	MG1526

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 1525

Chain	Residue
C	LYS51
C	ASP52
C	ATP1527

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 1526

Chain	Residue
C	ASP87
C	GLY88
C	SER151
C	ATP1527

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP C 1527

Chain	Residue
C	LEU31
C	GLY53
C	ASP87
C	GLY88
C	THR89
C	THR90
C	THR91
C	ILE150
C	ASN153
C	GLY414
C	GLY415
C	ILE454
C	ASP495
C	PO41525
C	MG1526

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 D 1525

Chain	Residue
D	ASP52
D	ATP1527

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 1526

Chain	Residue
D	ASP87
D	GLY88
D	SER151
D	ATP1527

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP D 1527

Chain	Residue
D	LEU31
D	GLY53
D	ASP87
D	GLY88
D	THR89
D	THR90
D	THR91
D	ILE150
D	ASN153
D	GLY414
D	GLY415
D	ILE454
D	ASP495
D	PO41525
D	MG1526

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 E 1525

Chain	Residue
E	LYS51
E	ASP52
E	ATP1527

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 1526

Chain	Residue
E	ASP87
E	GLY88
E	SER151
E	ATP1527

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP E 1527

Chain	Residue
E	THR89
E	THR90
E	THR91
E	ILE150
E	ASN153
E	GLY414
E	GLY415
E	ILE454
E	ASP495
E	PO41525
E	MG1526
E	LEU31
E	GLY53
E	ASP87
E	GLY88

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 F 1525

Chain	Residue
F	ASP52
F	ATP1527

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 1526

Chain	Residue
F	ASP87
F	GLY88
F	SER151
F	ATP1527

site_id	BC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP F 1527

Chain	Residue
F	LEU31
F	GLY53
F	ASP87
F	GLY88
F	THR89
F	THR90
F	THR91
F	ILE150
F	ASN153
F	GLY414
F	GLY415
F	ILE454
F	ASP495
F	PO41525
F	MG1526

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 G 1525

Chain	Residue
G	LYS51
G	ASP52
G	ATP1527

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG G 1526

Chain	Residue
G	ASP87
G	GLY88
G	SER151
G	ATP1527

site_id	CC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP G 1527

Chain	Residue
G	LEU31
G	GLY53
G	ASP87
G	GLY88
G	THR89
G	THR90
G	THR91
G	ILE150
G	ASN153
G	GLY414
G	GLY415
G	ILE454
G	ASP495
G	PO41525
G	MG1526

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 H 1525

Chain	Residue
H	ASP52
H	ASN153
H	MG1526
H	ATP1527

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG H 1526

Chain	Residue
H	ASP87
H	GLY88
H	PO41525
H	ATP1527

site_id	CC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP H 1527

Chain	Residue
H	LEU31
H	ASP52
H	GLY53
H	ASP87
H	GLY88
H	THR89
H	THR90
H	THR91
H	ASN153
H	GLY414
H	GLY415
H	ILE454
H	TYR478
H	ASN479
H	ALA480
H	ALA481
H	ILE493
H	ASP495
H	PO41525
H	MG1526

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 I 1525

Chain	Residue
I	ASP52
I	ASN153
I	MG1526
I	ATP1527

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG I 1526

Chain	Residue
I	ASP87
I	GLY88
I	PO41525
I	ATP1527

site_id	CC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP I 1527

Chain	Residue
I	LEU31
I	ASP52
I	GLY53
I	ASP87
I	GLY88
I	THR89
I	THR90
I	THR91
I	ASN153
I	GLY414
I	GLY415
I	ILE454
I	TYR478
I	ASN479
I	ALA480
I	ALA481
I	ILE493
I	ASP495
I	PO41525
I	MG1526

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 J 1525

Chain	Residue
J	ASP52
J	ASN153
J	MG1526
J	ATP1527

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG J 1526

Chain	Residue
J	ASP87
J	GLY88
J	PO41525
J	ATP1527

site_id	DC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP J 1527

Chain	Residue
J	LEU31
J	ASP52
J	GLY53
J	ASP87
J	GLY88
J	THR89
J	THR90
J	THR91
J	ASN153
J	GLY414
J	GLY415
J	ILE454
J	TYR478
J	ASN479
J	ALA480
J	ALA481
J	ILE493
J	ASP495
J	PO41525
J	MG1526

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 K 1525

Chain	Residue
K	ASP52
K	ASN153
K	MG1526
K	ATP1527

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG K 1526

Chain	Residue
K	ASP87
K	GLY88
K	PO41525
K	ATP1527

site_id	DC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP K 1527

Chain	Residue
K	LEU31
K	ASP52
K	GLY53
K	ASP87
K	GLY88
K	THR89
K	THR90
K	THR91
K	ASN153
K	GLY414
K	GLY415
K	ILE454
K	TYR478
K	ASN479
K	ALA480
K	ALA481
K	ILE493
K	ASP495
K	PO41525
K	MG1526

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 L 1525

Chain	Residue
L	ASP52
L	ASN153
L	MG1526
L	ATP1527

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG L 1526

Chain	Residue
L	ASP87
L	GLY88
L	PO41525
L	ATP1527

site_id	DC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP L 1527

Chain	Residue
L	LEU31
L	ASP52
L	GLY53
L	ASP87
L	GLY88
L	THR89
L	THR90
L	THR91
L	ASN153
L	GLY414
L	GLY415
L	ILE454
L	TYR478
L	ASN479
L	ALA480
L	ALA481
L	ILE493
L	ASP495
L	PO41525
L	MG1526

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 M 1525

Chain	Residue
M	ASP52
M	ASN153
M	MG1526
M	ATP1527

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG M 1526

Chain	Residue
M	ASP87
M	GLY88
M	PO41525
M	ATP1527

site_id	EC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP M 1527

Chain	Residue
M	LEU31
M	ASP52
M	GLY53
M	ASP87
M	GLY88
M	THR89
M	THR90
M	THR91
M	ASN153
M	GLY414
M	GLY415
M	ILE454
M	TYR478
M	ASN479
M	ALA480
M	ALA481
M	ILE493
M	ASP495
M	PO41525
M	MG1526

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 N 1525

Chain	Residue
N	ASP52
N	ASN153
N	MG1526
N	ATP1527

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG N 1526

Chain	Residue
N	ASP87
N	GLY88
N	PO41525
N	ATP1527

site_id	EC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP N 1527

Chain	Residue
N	LEU31
N	ASP52
N	GLY53
N	ASP87
N	GLY88
N	THR89
N	THR90
N	THR91
N	ASN153
N	GLY414
N	GLY415
N	ILE454
N	TYR478
N	ASN479
N	ALA480
N	ALA481
N	ILE493
N	ASP495
N	PO41525
N	MG1526

Functional Information from PROSITE/UniProt

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGVVaGGG

Chain	Residue	Details
A	ALA405-GLY416

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	154
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00600","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25174333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14517228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9285585","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1AON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PCQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WVL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00600","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25174333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14517228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9285585","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1AON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WVL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	70
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	14
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)