Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AB2

ATP-triggered molecular mechanics of the chaperonin GroEL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0009314	biological_process	response to radiation
A	0009408	biological_process	response to heat
A	0016020	cellular_component	membrane
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019068	biological_process	virion assembly
A	0042026	biological_process	protein refolding
A	0042802	molecular_function	identical protein binding
A	0051082	molecular_function	unfolded protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
A	1990220	cellular_component	GroEL-GroES complex
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006457	biological_process	protein folding
B	0009314	biological_process	response to radiation
B	0009408	biological_process	response to heat
B	0016020	cellular_component	membrane
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019068	biological_process	virion assembly
B	0042026	biological_process	protein refolding
B	0042802	molecular_function	identical protein binding
B	0051082	molecular_function	unfolded protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone
B	1990220	cellular_component	GroEL-GroES complex
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0009314	biological_process	response to radiation
C	0009408	biological_process	response to heat
C	0016020	cellular_component	membrane
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0019068	biological_process	virion assembly
C	0042026	biological_process	protein refolding
C	0042802	molecular_function	identical protein binding
C	0051082	molecular_function	unfolded protein binding
C	0140662	molecular_function	ATP-dependent protein folding chaperone
C	1990220	cellular_component	GroEL-GroES complex
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006457	biological_process	protein folding
D	0009314	biological_process	response to radiation
D	0009408	biological_process	response to heat
D	0016020	cellular_component	membrane
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0019068	biological_process	virion assembly
D	0042026	biological_process	protein refolding
D	0042802	molecular_function	identical protein binding
D	0051082	molecular_function	unfolded protein binding
D	0140662	molecular_function	ATP-dependent protein folding chaperone
D	1990220	cellular_component	GroEL-GroES complex
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006457	biological_process	protein folding
E	0009314	biological_process	response to radiation
E	0009408	biological_process	response to heat
E	0016020	cellular_component	membrane
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019068	biological_process	virion assembly
E	0042026	biological_process	protein refolding
E	0042802	molecular_function	identical protein binding
E	0051082	molecular_function	unfolded protein binding
E	0140662	molecular_function	ATP-dependent protein folding chaperone
E	1990220	cellular_component	GroEL-GroES complex
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006457	biological_process	protein folding
F	0009314	biological_process	response to radiation
F	0009408	biological_process	response to heat
F	0016020	cellular_component	membrane
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0019068	biological_process	virion assembly
F	0042026	biological_process	protein refolding
F	0042802	molecular_function	identical protein binding
F	0051082	molecular_function	unfolded protein binding
F	0140662	molecular_function	ATP-dependent protein folding chaperone
F	1990220	cellular_component	GroEL-GroES complex
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0009314	biological_process	response to radiation
G	0009408	biological_process	response to heat
G	0016020	cellular_component	membrane
G	0016853	molecular_function	isomerase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0019068	biological_process	virion assembly
G	0042026	biological_process	protein refolding
G	0042802	molecular_function	identical protein binding
G	0051082	molecular_function	unfolded protein binding
G	0140662	molecular_function	ATP-dependent protein folding chaperone
G	1990220	cellular_component	GroEL-GroES complex
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006457	biological_process	protein folding
H	0009314	biological_process	response to radiation
H	0009408	biological_process	response to heat
H	0016020	cellular_component	membrane
H	0016853	molecular_function	isomerase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0019068	biological_process	virion assembly
H	0042026	biological_process	protein refolding
H	0042802	molecular_function	identical protein binding
H	0051082	molecular_function	unfolded protein binding
H	0140662	molecular_function	ATP-dependent protein folding chaperone
H	1990220	cellular_component	GroEL-GroES complex
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006457	biological_process	protein folding
I	0009314	biological_process	response to radiation
I	0009408	biological_process	response to heat
I	0016020	cellular_component	membrane
I	0016853	molecular_function	isomerase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0019068	biological_process	virion assembly
I	0042026	biological_process	protein refolding
I	0042802	molecular_function	identical protein binding
I	0051082	molecular_function	unfolded protein binding
I	0140662	molecular_function	ATP-dependent protein folding chaperone
I	1990220	cellular_component	GroEL-GroES complex
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006457	biological_process	protein folding
J	0009314	biological_process	response to radiation
J	0009408	biological_process	response to heat
J	0016020	cellular_component	membrane
J	0016853	molecular_function	isomerase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0019068	biological_process	virion assembly
J	0042026	biological_process	protein refolding
J	0042802	molecular_function	identical protein binding
J	0051082	molecular_function	unfolded protein binding
J	0140662	molecular_function	ATP-dependent protein folding chaperone
J	1990220	cellular_component	GroEL-GroES complex
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006457	biological_process	protein folding
K	0009314	biological_process	response to radiation
K	0009408	biological_process	response to heat
K	0016020	cellular_component	membrane
K	0016853	molecular_function	isomerase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0019068	biological_process	virion assembly
K	0042026	biological_process	protein refolding
K	0042802	molecular_function	identical protein binding
K	0051082	molecular_function	unfolded protein binding
K	0140662	molecular_function	ATP-dependent protein folding chaperone
K	1990220	cellular_component	GroEL-GroES complex
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006457	biological_process	protein folding
L	0009314	biological_process	response to radiation
L	0009408	biological_process	response to heat
L	0016020	cellular_component	membrane
L	0016853	molecular_function	isomerase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0019068	biological_process	virion assembly
L	0042026	biological_process	protein refolding
L	0042802	molecular_function	identical protein binding
L	0051082	molecular_function	unfolded protein binding
L	0140662	molecular_function	ATP-dependent protein folding chaperone
L	1990220	cellular_component	GroEL-GroES complex
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006457	biological_process	protein folding
M	0009314	biological_process	response to radiation
M	0009408	biological_process	response to heat
M	0016020	cellular_component	membrane
M	0016853	molecular_function	isomerase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0019068	biological_process	virion assembly
M	0042026	biological_process	protein refolding
M	0042802	molecular_function	identical protein binding
M	0051082	molecular_function	unfolded protein binding
M	0140662	molecular_function	ATP-dependent protein folding chaperone
M	1990220	cellular_component	GroEL-GroES complex
N	0000166	molecular_function	nucleotide binding
N	0000287	molecular_function	magnesium ion binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006457	biological_process	protein folding
N	0009314	biological_process	response to radiation
N	0009408	biological_process	response to heat
N	0016020	cellular_component	membrane
N	0016853	molecular_function	isomerase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0019068	biological_process	virion assembly
N	0042026	biological_process	protein refolding
N	0042802	molecular_function	identical protein binding
N	0051082	molecular_function	unfolded protein binding
N	0140662	molecular_function	ATP-dependent protein folding chaperone
N	1990220	cellular_component	GroEL-GroES complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP A 1525

Chain	Residue
A	LEU31
A	ASN153
A	SER154
A	GLY415
A	ILE454
A	ASN479
A	ASP495
A	PO41528
A	GLY32
A	VAL54
A	ASP87
A	GLY88
A	THR89
A	THR90
A	THR91
A	ILE150

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 1528

Chain	Residue
A	LEU31
A	THR90
A	ASN153
A	ATP1525

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP B 1525

Chain	Residue
B	LEU31
B	GLY32
B	VAL54
B	ASP87
B	GLY88
B	THR89
B	THR90
B	THR91
B	ILE150
B	ASN153
B	SER154
B	GLY415
B	ILE454
B	ASN479
B	ASP495
B	PO41528

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 1528

Chain	Residue
B	LEU31
B	THR90
B	ASN153
B	ATP1525

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP C 1526

Chain	Residue
C	LEU31
C	GLY32
C	VAL54
C	ASP87
C	GLY88
C	THR89
C	THR90
C	THR91
C	ILE150
C	ASN153
C	SER154
C	GLY415
C	ILE454
C	ASN479
C	ASP495
C	PO41528

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 1528

Chain	Residue
C	LEU31
C	THR90
C	ASN153
C	ATP1526

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP D 1525

Chain	Residue
D	LEU31
D	GLY32
D	VAL54
D	ASP87
D	GLY88
D	THR89
D	THR90
D	THR91
D	ILE150
D	ASN153
D	SER154
D	GLY415
D	ILE454
D	ASN479
D	ASP495
D	PO41528

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 D 1528

Chain	Residue
D	LEU31
D	THR90
D	ASN153
D	ATP1525

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP E 1525

Chain	Residue
E	LEU31
E	GLY32
E	VAL54
E	ASP87
E	GLY88
E	THR89
E	THR90
E	THR91
E	ILE150
E	ASN153
E	SER154
E	GLY415
E	ILE454
E	ASN479
E	ASP495
E	PO41528

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 1528

Chain	Residue
E	ATP1525
E	LEU31
E	THR90
E	ASN153

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP F 1525

Chain	Residue
F	LEU31
F	GLY32
F	VAL54
F	ASP87
F	GLY88
F	THR89
F	THR90
F	THR91
F	ILE150
F	ASN153
F	SER154
F	GLY415
F	ILE454
F	ASN479
F	ASP495
F	PO41528

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 F 1528

Chain	Residue
F	LEU31
F	THR90
F	ASN153
F	ATP1525

site_id	BC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP G 1525

Chain	Residue
G	LEU31
G	GLY32
G	VAL54
G	ASP87
G	GLY88
G	THR89
G	THR90
G	THR91
G	ILE150
G	ASN153
G	SER154
G	GLY415
G	ILE454
G	ASN479
G	ASP495
G	PO41528

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 G 1528

Chain	Residue
G	LEU31
G	THR90
G	ASN153
G	ATP1525

site_id	BC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP H 1527

Chain	Residue
H	LEU31
H	GLY32
H	ASP87
H	GLY88
H	THR89
H	THR90
H	THR91
H	ILE150
H	ASN153
H	SER154
H	GLY415
H	ILE493
H	ASP495
H	PO41528

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 H 1528

Chain	Residue
H	ASP52
H	ASN153
H	ATP1527

site_id	BC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP I 1525

Chain	Residue
I	LEU31
I	GLY32
I	ASP87
I	GLY88
I	THR89
I	THR90
I	THR91
I	ILE150
I	ASN153
I	SER154
I	GLY415
I	ILE493
I	ASP495
I	PO41528

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 I 1528

Chain	Residue
I	ASP52
I	ASN153
I	ATP1525

site_id	CC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP J 1526

Chain	Residue
J	LEU31
J	GLY32
J	ASP87
J	GLY88
J	THR89
J	THR90
J	THR91
J	ILE150
J	ASN153
J	SER154
J	GLY415
J	ILE493
J	ASP495
J	PO41528

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 J 1528

Chain	Residue
J	ASP52
J	ASN153
J	ATP1526

site_id	CC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP K 1527

Chain	Residue
K	LEU31
K	GLY32
K	ASP87
K	GLY88
K	THR89
K	THR90
K	THR91
K	ILE150
K	ASN153
K	SER154
K	GLY415
K	ILE493
K	ASP495
K	PO41528

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 K 1528

Chain	Residue
K	ASP52
K	ASN153
K	ATP1527

site_id	CC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP L 1527

Chain	Residue
L	LEU31
L	GLY32
L	ASP87
L	GLY88
L	THR89
L	THR90
L	THR91
L	ILE150
L	ASN153
L	SER154
L	GLY415
L	ILE493
L	ASP495
L	PO41528

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 L 1528

Chain	Residue
L	ASP52
L	ASN153
L	ATP1527

site_id	CC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP M 1527

Chain	Residue
M	LEU31
M	GLY32
M	ASP87
M	GLY88
M	THR89
M	THR90
M	THR91
M	ILE150
M	ASN153
M	SER154
M	GLY415
M	ILE493
M	ASP495
M	PO41528

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 M 1528

Chain	Residue
M	ASP52
M	ASN153
M	ATP1527

site_id	CC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP N 1527

Chain	Residue
N	LEU31
N	GLY32
N	ASP87
N	GLY88
N	THR89
N	THR90
N	THR91
N	ILE150
N	ASN153
N	SER154
N	GLY415
N	ILE493
N	ASP495
N	PO41528

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 N 1528

Chain	Residue
N	ASP52
N	ASN153
N	ATP1527

Functional Information from PROSITE/UniProt

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGVVaGGG

Chain	Residue	Details
A	ALA405-GLY416

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00600, ECO:0000269\|PubMed:25174333, ECO:0000305\|PubMed:14517228, ECO:0000305\|PubMed:9285585, ECO:0007744\|PDB:1AON, ECO:0007744\|PDB:1PCQ, ECO:0007744\|PDB:1PF9, ECO:0007744\|PDB:3WVL

Chain	Residue	Details
A	THR30
B	ASP495
C	THR30
C	ASP87
C	GLY415
C	ASN479
C	ASP495
D	THR30
D	ASP87
D	GLY415
D	ASN479
A	ASP87
D	ASP495
E	THR30
E	ASP87
E	GLY415
E	ASN479
E	ASP495
F	THR30
F	ASP87
F	GLY415
F	ASN479
A	GLY415
F	ASP495
G	THR30
G	ASP87
G	GLY415
G	ASN479
G	ASP495
H	THR30
H	ASP87
H	GLY415
H	ASN479
A	ASN479
H	ASP495
I	THR30
I	ASP87
I	GLY415
I	ASN479
I	ASP495
J	THR30
J	ASP87
J	GLY415
J	ASN479
A	ASP495
J	ASP495
K	THR30
K	ASP87
K	GLY415
K	ASN479
K	ASP495
L	THR30
L	ASP87
L	GLY415
L	ASN479
B	THR30
L	ASP495
M	THR30
M	ASP87
M	GLY415
M	ASN479
M	ASP495
N	THR30
N	ASP87
N	GLY415
N	ASN479
B	ASP87
N	ASP495
B	GLY415
B	ASN479

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00600, ECO:0000269\|PubMed:25174333, ECO:0000305\|PubMed:14517228, ECO:0000305\|PubMed:9285585, ECO:0007744\|PDB:1AON, ECO:0007744\|PDB:1PF9, ECO:0007744\|PDB:3WVL

Chain	Residue	Details
A	LYS51
J	LYS51
K	LYS51
L	LYS51
M	LYS51
N	LYS51
B	LYS51
C	LYS51
D	LYS51
E	LYS51
F	LYS51
G	LYS51
H	LYS51
I	LYS51

site_id	SWS_FT_FI3
Number of Residues	70
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
A	LYS34
B	LYS390
C	LYS34
C	LYS51
C	LYS277
C	LYS321
C	LYS390
D	LYS34
D	LYS51
D	LYS277
D	LYS321
A	LYS51
D	LYS390
E	LYS34
E	LYS51
E	LYS277
E	LYS321
E	LYS390
F	LYS34
F	LYS51
F	LYS277
F	LYS321
A	LYS277
F	LYS390
G	LYS34
G	LYS51
G	LYS277
G	LYS321
G	LYS390
H	LYS34
H	LYS51
H	LYS277
H	LYS321
A	LYS321
H	LYS390
I	LYS34
I	LYS51
I	LYS277
I	LYS321
I	LYS390
J	LYS34
J	LYS51
J	LYS277
J	LYS321
A	LYS390
J	LYS390
K	LYS34
K	LYS51
K	LYS277
K	LYS321
K	LYS390
L	LYS34
L	LYS51
L	LYS277
L	LYS321
B	LYS34
L	LYS390
M	LYS34
M	LYS51
M	LYS277
M	LYS321
M	LYS390
N	LYS34
N	LYS51
N	LYS277
N	LYS321
B	LYS51
N	LYS390
B	LYS277
B	LYS321

site_id	SWS_FT_FI4
Number of Residues	14
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
A	LYS117
J	LYS117
K	LYS117
L	LYS117
M	LYS117
N	LYS117
B	LYS117
C	LYS117
D	LYS117
E	LYS117
F	LYS117
G	LYS117
H	LYS117
I	LYS117

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)