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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4A97

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with zopiclone

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
F0004888molecular_functiontransmembrane signaling receptor activity
F0005216molecular_functionmonoatomic ion channel activity
F0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
F0006811biological_processmonoatomic ion transport
F0016020cellular_componentmembrane
F0034220biological_processmonoatomic ion transmembrane transport
G0004888molecular_functiontransmembrane signaling receptor activity
G0005216molecular_functionmonoatomic ion channel activity
G0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
G0006811biological_processmonoatomic ion transport
G0016020cellular_componentmembrane
G0034220biological_processmonoatomic ion transmembrane transport
H0004888molecular_functiontransmembrane signaling receptor activity
H0005216molecular_functionmonoatomic ion channel activity
H0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
H0006811biological_processmonoatomic ion transport
H0016020cellular_componentmembrane
H0034220biological_processmonoatomic ion transmembrane transport
I0004888molecular_functiontransmembrane signaling receptor activity
I0005216molecular_functionmonoatomic ion channel activity
I0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
I0006811biological_processmonoatomic ion transport
I0016020cellular_componentmembrane
I0034220biological_processmonoatomic ion transmembrane transport
J0004888molecular_functiontransmembrane signaling receptor activity
J0005216molecular_functionmonoatomic ion channel activity
J0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
J0006811biological_processmonoatomic ion transport
J0016020cellular_componentmembrane
J0034220biological_processmonoatomic ion transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ZPC A 1318
ChainResidue
AGLU77
EGLU150
AGLU131
APRO132
APHE133
ATYR175
AHIS177
ETYR38
EVAL40
EARG91
site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ZPC B 1318
ChainResidue
APHE19
ATYR38
AARG91
AILE101
AASN103
AGLU150
BGLU77
BGLU131
BPRO132
BPHE133
BTYR175
BHIS177
BPHE188
site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ZPC C 1318
ChainResidue
BPHE19
BVAL40
BARG91
BASN103
BGLU150
CGLU77
CGLU131
CPRO132
CPHE133
CTYR175
CHIS177
CVAL181
site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ZPC D 1318
ChainResidue
CPHE19
CTYR38
CARG91
CILE101
CASN103
CGLU150
DGLU77
DPRO132
DPHE133
DTYR175
DHIS177
DLEU178
DVAL181
site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ZPC E 1318
ChainResidue
DPHE19
DTYR38
DVAL40
DARG91
DMET93
DILE101
DASN103
DGLU150
EPRO132
EPHE133
ETYR175
EHIS177
EVAL181
EPHE188
site_idAC6
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ZPC F 1318
ChainResidue
FGLU77
FGLU131
FPRO132
FPHE133
FTYR175
FHIS177
FPHE188
JPHE19
JARG91
JILE101
JASN103
JGLU150
site_idAC7
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ZPC G 1318
ChainResidue
FPHE19
FTYR38
FARG91
FMET93
FASN103
FGLU150
GGLU131
GPRO132
GPHE133
GTYR175
GHIS177
GLEU178
GPHE188
site_idAC8
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ZPC H 1318
ChainResidue
HPHE188
GPHE19
GTYR38
GVAL40
GARG91
GILE101
GASN103
GGLU150
HGLU77
HGLU131
HPHE133
HHIS177
HVAL181
site_idAC9
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ZPC I 1318
ChainResidue
HPHE19
HTYR38
HARG91
HILE101
HASN103
HGLU150
IGLU77
IPHE133
IHIS177
ILEU178
IVAL181
site_idBC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ZPC J 1318
ChainResidue
IPHE19
ITYR38
IARG91
IILE101
IASN103
IGLU150
JGLU77
JGLU131
JPRO132
JPHE133
JTYR175
JHIS177
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues600
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues220
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues90
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsMotif: {"description":"Cys-loop"}
ChainResidueDetails

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PDB entries from 2025-12-24

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