4A5T
STRUCTURAL BASIS FOR THE CONFORMATIONAL MODULATION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| S | 0002020 | molecular_function | protease binding |
| S | 0004175 | molecular_function | endopeptidase activity |
| S | 0004252 | molecular_function | serine-type endopeptidase activity |
| S | 0005102 | molecular_function | signaling receptor binding |
| S | 0005515 | molecular_function | protein binding |
| S | 0005576 | cellular_component | extracellular region |
| S | 0005615 | cellular_component | extracellular space |
| S | 0005886 | cellular_component | plasma membrane |
| S | 0006508 | biological_process | proteolysis |
| S | 0007596 | biological_process | blood coagulation |
| S | 0008236 | molecular_function | serine-type peptidase activity |
| S | 0008285 | biological_process | negative regulation of cell population proliferation |
| S | 0009897 | cellular_component | external side of plasma membrane |
| S | 0009986 | cellular_component | cell surface |
| S | 0010812 | biological_process | negative regulation of cell-substrate adhesion |
| S | 0019899 | molecular_function | enzyme binding |
| S | 0019900 | molecular_function | kinase binding |
| S | 0019904 | molecular_function | protein domain specific binding |
| S | 0022617 | biological_process | extracellular matrix disassembly |
| S | 0031093 | cellular_component | platelet alpha granule lumen |
| S | 0034185 | molecular_function | apolipoprotein binding |
| S | 0042246 | biological_process | tissue regeneration |
| S | 0042730 | biological_process | fibrinolysis |
| S | 0043536 | biological_process | positive regulation of blood vessel endothelial cell migration |
| S | 0045445 | biological_process | myoblast differentiation |
| S | 0046716 | biological_process | muscle cell cellular homeostasis |
| S | 0048771 | biological_process | tissue remodeling |
| S | 0051087 | molecular_function | protein-folding chaperone binding |
| S | 0051702 | biological_process | biological process involved in interaction with symbiont |
| S | 0051918 | biological_process | negative regulation of fibrinolysis |
| S | 0051919 | biological_process | positive regulation of fibrinolysis |
| S | 0060707 | biological_process | trophoblast giant cell differentiation |
| S | 0060716 | biological_process | labyrinthine layer blood vessel development |
| S | 0062023 | cellular_component | collagen-containing extracellular matrix |
| S | 0070062 | cellular_component | extracellular exosome |
| S | 0071674 | biological_process | mononuclear cell migration |
| S | 0072562 | cellular_component | blood microparticle |
| S | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| S | 0098978 | cellular_component | glutamatergic synapse |
| S | 0099183 | biological_process | trans-synaptic signaling by BDNF, modulating synaptic transmission |
| S | 1990405 | molecular_function | protein antigen binding |
| S | 2000048 | biological_process | negative regulation of cell-cell adhesion mediated by cadherin |
Functional Information from PROSITE/UniProt
| site_id | PS00021 |
| Number of Residues | 14 |
| Details | KRINGLE_1 Kringle domain signature. YCRNpdndpqgpWC |
| Chain | Residue | Details |
| S | TYR132-CYS145 | |
| S | TYR214-CYS226 | |
| S | TYR304-CYS316 | |
| S | TYR406-CYS418 | |
| S | TYR511-CYS524 |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| S | LEU599-CYS604 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
| Chain | Residue | Details |
| S | ASP735-VAL746 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| S | HIS603 | |
| S | ASP646 | |
| S | SER741 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: |
| Chain | Residue | Details |
| S | ARG117 | |
| S | ASP139 | |
| S | ARG153 | |
| S | ASP413 | |
| S | ARG426 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by stromelysin-1 |
| Chain | Residue | Details |
| S | GLU59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Interacts with fibrin |
| Chain | Residue | Details |
| S | ARG115 | |
| S | ARG117 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by stromelysin-19 |
| Chain | Residue | Details |
| S | PRO447 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by plasminogen activator |
| Chain | Residue | Details |
| S | ARG561 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:9201958 |
| Chain | Residue | Details |
| S | SER578 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| S | SER669 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:3356193, ECO:0000269|PubMed:9054441 |
| Chain | Residue | Details |
| S | SER249 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:3356193 |
| Chain | Residue | Details |
| S | ASN289 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:3356193 |
| Chain | Residue | Details |
| S | THR346 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| S | HIS603 | proton shuttle (general acid/base) |
| S | ASP646 | electrostatic stabiliser, modifies pKa |
| S | SER741 | covalent catalysis, proton shuttle (general acid/base) |
| S | GLY742 | electrostatic stabiliser |
