4A2O
STRUCTURE OF THE HUMAN EOSINOPHIL CATIONIC PROTEIN IN COMPLEX WITH SULFATE ANIONS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0043152 | biological_process | induction of bacterial agglutination |
| A | 0045087 | biological_process | innate immune response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| B | 0001530 | molecular_function | lipopolysaccharide binding |
| B | 0002227 | biological_process | innate immune response in mucosa |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004540 | molecular_function | RNA nuclease activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006935 | biological_process | chemotaxis |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0043152 | biological_process | induction of bacterial agglutination |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1134 |
| Chain | Residue |
| A | ARG34 |
| A | ARG36 |
| A | LYS38 |
| A | ASN39 |
| A | HOH2074 |
| A | HOH2075 |
| B | ARG104 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1135 |
| Chain | Residue |
| A | HOH2191 |
| A | ARG1 |
| A | ARG7 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1136 |
| Chain | Residue |
| A | ARG77 |
| A | ARG104 |
| B | ARG36 |
| B | HOH2060 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1137 |
| Chain | Residue |
| A | ARG121 |
| A | ARG121 |
| A | HOH2193 |
| A | HOH2193 |
| A | HOH2194 |
| A | HOH2194 |
| A | HOH2195 |
| A | HOH2195 |
| B | VAL52 |
| B | PRO123 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1138 |
| Chain | Residue |
| A | ARG28 |
| A | ASN32 |
| A | ARG61 |
| A | ARG66 |
| A | HOH2055 |
| A | HOH2112 |
| A | HOH2196 |
| A | HOH2197 |
| B | ARG22 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1134 |
| Chain | Residue |
| A | ARG104 |
| B | ARG34 |
| B | LYS38 |
| B | ASN39 |
| B | HOH2061 |
| B | HOH2068 |
| B | HOH2072 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1135 |
| Chain | Residue |
| B | GLN14 |
| B | LYS38 |
| B | HIS128 |
| B | HOH2016 |
| B | HOH2024 |
| B | HOH2058 |
| B | HOH2166 |
| B | HOH2167 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1136 |
| Chain | Residue |
| B | ARG1 |
| B | ARG7 |
| B | HOH2170 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1137 |
| Chain | Residue |
| A | ARG36 |
| A | HOH2068 |
| B | ARG77 |
| B | ARG104 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1138 |
| Chain | Residue |
| B | ASN57 |
| B | GLN58 |
| B | ARG73 |
| B | ARG75 |
| B | ARG75 |
| B | HOH2091 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1139 |
| Chain | Residue |
| A | ARG75 |
| A | HOH2096 |
| A | HOH2099 |
| B | ASN87 |
| B | PRO88 |
| B | GLY89 |
| B | HOH2119 |
| B | HOH2172 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1140 |
| Chain | Residue |
| A | GLN58 |
| A | SER59 |
| A | HOH2110 |
| B | ARG97 |
| B | HOH2045 |
| B | HOH2134 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1141 |
| Chain | Residue |
| A | HOH2044 |
| B | ARG28 |
| B | ASN32 |
| B | ARG61 |
| B | ARG66 |
| B | HOH2132 |
| B | HOH2173 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1142 |
| Chain | Residue |
| A | ASN57 |
| A | GLN58 |
| A | ARG75 |
| A | HOH2101 |
| B | ASN87 |
| B | ALA90 |
| B | ARG97 |
| B | HOH2133 |
| B | HOH2174 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF |
| Chain | Residue | Details |
| A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS15 | |
| B | HIS15 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS128 | |
| B | HIS128 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS38 | |
| B | LYS38 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: May be involved in LPS-binding |
| Chain | Residue | Details |
| A | TYR33 | |
| B | TYR33 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: May be involved in LPS- and LTA-binding |
| Chain | Residue | Details |
| A | TRP35 | |
| B | TRP35 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:18694936 |
| Chain | Residue | Details |
| A | TYR33 | |
| B | TYR33 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN57 | |
| A | ASN65 | |
| A | ASN92 | |
| B | ASN57 | |
| B | ASN65 | |
| B | ASN92 |
