4A26

The crystal structure of Leishmania major N5,N10- methylenetetrahydrofolate dehydrogenase/cyclohydrolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
A	0004487	molecular_function	methylenetetrahydrofolate dehydrogenase (NAD+) activity
A	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0006730	biological_process	one-carbon metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016787	molecular_function	hydrolase activity
A	0020023	cellular_component	kinetoplast
A	0035999	biological_process	tetrahydrofolate interconversion
B	0003824	molecular_function	catalytic activity
B	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
B	0004487	molecular_function	methylenetetrahydrofolate dehydrogenase (NAD+) activity
B	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
B	0005829	cellular_component	cytosol
B	0006730	biological_process	one-carbon metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016787	molecular_function	hydrolase activity
B	0020023	cellular_component	kinetoplast
B	0035999	biological_process	tetrahydrofolate interconversion

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1297

Chain	Residue
A	LYS136
B	ARG171
B	SER195

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Functional Information from PROSITE/UniProt

site_id	PS00767
Number of Residues	9
Details	THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTI

Chain	Residue	Details
A	PRO272-ILE280

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