4A21
Structure of Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase bound to sulfate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0035375 | molecular_function | zymogen binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0035375 | molecular_function | zymogen binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0009274 | cellular_component | peptidoglycan-based cell wall |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016832 | molecular_function | aldehyde-lyase activity |
| C | 0035375 | molecular_function | zymogen binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0009274 | cellular_component | peptidoglycan-based cell wall |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016832 | molecular_function | aldehyde-lyase activity |
| D | 0035375 | molecular_function | zymogen binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1344 |
| Chain | Residue |
| A | SER255 |
| A | VAL275 |
| A | ASP276 |
| A | THR277 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1345 |
| Chain | Residue |
| A | SER53 |
| A | GLY55 |
| A | HOH2215 |
| B | ARG314 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 1346 |
| Chain | Residue |
| A | HIS93 |
| A | ASP95 |
| A | MET129 |
| A | GLU159 |
| A | LYS272 |
| A | ASN274 |
| A | GLN51 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1347 |
| Chain | Residue |
| A | THR94 |
| A | ASP95 |
| A | CYS97 |
| A | MET129 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1344 |
| Chain | Residue |
| A | ARG314 |
| A | HOH2201 |
| B | SER53 |
| B | THR54 |
| B | GLY55 |
| B | HOH2043 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1345 |
| Chain | Residue |
| B | GLY253 |
| B | GLY254 |
| B | SER255 |
| B | ASP276 |
| B | THR277 |
| B | HOH2170 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1344 |
| Chain | Residue |
| C | GLY253 |
| C | GLY254 |
| C | SER255 |
| C | ASN274 |
| C | ASP276 |
| C | THR277 |
| C | HOH2136 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1345 |
| Chain | Residue |
| C | SER53 |
| C | GLY55 |
| D | ARG314 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1344 |
| Chain | Residue |
| C | ARG314 |
| D | SER53 |
| D | THR54 |
| D | GLY55 |
| D | HOH2178 |
| D | HOH2179 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1345 |
| Chain | Residue |
| D | GLY253 |
| D | SER255 |
| D | VAL275 |
| D | ASP276 |
| D | THR277 |
Functional Information from PROSITE/UniProt
| site_id | PS00602 |
| Number of Residues | 12 |
| Details | ALDOLASE_CLASS_II_1 Fructose-bisphosphate aldolase class-II signature 1. Yp..VNVa.LHtDHC |
| Chain | Residue | Details |
| A | TYR86-CYS97 |
| site_id | PS00806 |
| Number of Residues | 12 |
| Details | ALDOLASE_CLASS_II_2 Fructose-bisphosphate aldolase class-II signature 2. LEiEIGvvGGeE |
| Chain | Residue | Details |
| A | LEU158-GLU169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
