4A0Z

Structure of the global transcription regulator FapR from Staphylococcus aureus in complex with malonyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0045717	biological_process	negative regulation of fatty acid biosynthetic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE MLC A 201

Chain	Residue
A	PHE103
A	HOH2060
A	HOH2071
A	HOH2097
A	HOH2098
A	HOH2099
B	ASN119
B	VAL123
B	THR130
B	LEU132
B	THR133
A	ALA109
B	HIS134
B	LYS162
B	PHE185
B	ASP187
B	ARG189
A	ARG110
A	GLY111
A	PHE140
A	ILE141
A	GLU142
A	LYS143
A	HOH2059

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site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE MLC B 201

Chain	Residue
A	ASN119
A	VAL123
A	THR133
A	HIS134
A	LYS162
A	PHE185
A	ASP187
A	HOH2062
B	PHE103
B	ALA109
B	ARG110
B	GLY111
B	PHE140
B	ILE141
B	GLU142
B	LYS143
B	HOH2027
B	HOH2051

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