3ZYS

Human dynamin 1 deltaPRD polymer stabilized with GMPPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0006915	biological_process	apoptotic process
B	0006952	biological_process	defense response
B	0007165	biological_process	signal transduction
B	0008017	molecular_function	microtubule binding
B	0009615	biological_process	response to virus
B	0016020	cellular_component	membrane
B	0031965	cellular_component	nuclear membrane
B	0034340	biological_process	response to type I interferon
B	0042802	molecular_function	identical protein binding
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051607	biological_process	defense response to virus
B	0070106	biological_process	interleukin-27-mediated signaling pathway
B	0140374	biological_process	antiviral innate immune response
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005874	cellular_component	microtubule
E	0006915	biological_process	apoptotic process
E	0006952	biological_process	defense response
E	0007165	biological_process	signal transduction
E	0008017	molecular_function	microtubule binding
E	0009615	biological_process	response to virus
E	0016020	cellular_component	membrane
E	0031965	cellular_component	nuclear membrane
E	0034340	biological_process	response to type I interferon
E	0042802	molecular_function	identical protein binding
E	0045071	biological_process	negative regulation of viral genome replication
E	0045087	biological_process	innate immune response
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051607	biological_process	defense response to virus
E	0070106	biological_process	interleukin-27-mediated signaling pathway
E	0140374	biological_process	antiviral innate immune response

Functional Information from PROSITE/UniProt

site_id	PS00410
Number of Residues	10
Details	G_DYNAMIN_1 Dynamin-type guanine nucleotide-binding (G) domain signature. LPRGSGIVTR

Chain	Residue	Details
A	LEU57-ARG66
B	LEU95-ARG104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
B	GLY77
B	ASP178
B	THR247
E	GLY77
E	ASP178
E	THR247

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine; in Interferon-induced GTP-binding protein Mx1; alternate => ECO:0000269|Ref.9

Chain	Residue	Details
B	MET1
E	MET1
A	LYS206
A	ASP208
D	GLY43
D	SER45
D	LYS206
D	ASP208

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:26612256, ECO:0000269|PubMed:30069048, ECO:0007744|PDB:2X2E, ECO:0007744|PDB:2X2F, ECO:0007744|PDB:5D3Q, ECO:0007744|PDB:6DLU

Chain	Residue	Details
A	LYS44
D	GLN239
A	SER46
A	ASN236
A	ARG237
A	GLN239
D	LYS44
D	SER46
D	ASN236
D	ARG237

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:26612256, ECO:0007744|PDB:5D3Q

Chain	Residue	Details
A	ARG59
D	ARG59

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0007744|PDB:2X2E, ECO:0007744|PDB:2X2F

Chain	Residue	Details
A	GLY60
D	GLY60

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:26612256, ECO:0000269|PubMed:30069048, ECO:0007744|PDB:2X2E, ECO:0007744|PDB:5D3Q, ECO:0007744|PDB:6DLU

Chain	Residue	Details
A	ASP211
D	ASP211

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P39053

Chain	Residue	Details
A	TYR80
D	TYR80

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; alternate => ECO:0000250|UniProtKB:P39053

Chain	Residue	Details
A	TYR125
D	TYR125

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P39053

Chain	Residue	Details
A	SER306
D	SER306

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