Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3ZYS

Human dynamin 1 deltaPRD polymer stabilized with GMPPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0000166	molecular_function	nucleotide binding
B	0002376	biological_process	immune system process
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0005886	cellular_component	plasma membrane
B	0006915	biological_process	apoptotic process
B	0006952	biological_process	defense response
B	0007165	biological_process	signal transduction
B	0008017	molecular_function	microtubule binding
B	0009615	biological_process	response to virus
B	0016020	cellular_component	membrane
B	0016185	biological_process	synaptic vesicle budding from presynaptic endocytic zone membrane
B	0031965	cellular_component	nuclear membrane
B	0034340	biological_process	response to type I interferon
B	0042802	molecular_function	identical protein binding
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0045202	cellular_component	synapse
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051607	biological_process	defense response to virus
B	0070106	biological_process	interleukin-27-mediated signaling pathway
B	0098793	cellular_component	presynapse
B	0140374	biological_process	antiviral innate immune response
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
E	0000166	molecular_function	nucleotide binding
E	0002376	biological_process	immune system process
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005874	cellular_component	microtubule
E	0005886	cellular_component	plasma membrane
E	0006915	biological_process	apoptotic process
E	0006952	biological_process	defense response
E	0007165	biological_process	signal transduction
E	0008017	molecular_function	microtubule binding
E	0009615	biological_process	response to virus
E	0016020	cellular_component	membrane
E	0016185	biological_process	synaptic vesicle budding from presynaptic endocytic zone membrane
E	0031965	cellular_component	nuclear membrane
E	0034340	biological_process	response to type I interferon
E	0042802	molecular_function	identical protein binding
E	0045071	biological_process	negative regulation of viral genome replication
E	0045087	biological_process	innate immune response
E	0045202	cellular_component	synapse
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051607	biological_process	defense response to virus
E	0070106	biological_process	interleukin-27-mediated signaling pathway
E	0098793	cellular_component	presynapse
E	0140374	biological_process	antiviral innate immune response

Functional Information from PROSITE/UniProt

site_id	PS00410
Number of Residues	10
Details	G_DYNAMIN_1 Dynamin-type guanine nucleotide-binding (G) domain signature. LPRGSGIVTR

Chain	Residue	Details
A	LEU57-ARG66
B	LEU95-ARG104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	532
Details	Domain: {"description":"Dynamin-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	14
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30069048","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DLU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X2F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20428113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26612256","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30069048","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DLU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P39053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; alternate","evidences":[{"source":"UniProtKB","id":"P39053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P39053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	212
Details	Domain: {"description":"PH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)