3ZYQ

Crystal structure of the tandem VHS and FYVE domains of Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS-Hrs) at 1.48 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035091	molecular_function	phosphatidylinositol binding
A	0043130	molecular_function	ubiquitin binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1222

Chain	Residue
A	CYS166
A	CYS169
A	CYS190
A	CYS193

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1223

Chain	Residue
A	CYS182
A	CYS185
A	CYS212
A	CYS215

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 A 1224

Chain	Residue
A	ALA163
A	HIS180
A	HIS181
A	ARG183
A	ARG210
A	HOH2107
A	HOH2124
A	HOH2125
A	HOH2127
A	HOH2148
A	HOH2150
A	VAL161

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1225

Chain	Residue
A	ARG10
A	ASP13
A	LYS14
A	TYR197
A	HOH2103
A	HOH2147

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1226

Chain	Residue
A	MET176
A	THR177
A	ARG178
A	HIS180
A	HOH2118
A	HOH2120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Domain: {"description":"VHS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00218","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Zinc finger: {"description":"FYVE-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00091","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00091","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---