3ZVY
PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1365 |
| Chain | Residue |
| A | CYS302 |
| A | CYS305 |
| A | CYS313 |
| A | CYS316 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1366 |
| Chain | Residue |
| A | CYS318 |
| A | CYS321 |
| A | HIS341 |
| A | CYS344 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1367 |
| Chain | Residue |
| A | CYS336 |
| A | CYS360 |
| A | CYS363 |
| A | CYS333 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1368 |
| Chain | Residue |
| A | HIS319 |
| A | GLU362 |
| B | HIS304 |
| B | CL1371 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1366 |
| Chain | Residue |
| B | CYS302 |
| B | CYS305 |
| B | CYS313 |
| B | CYS316 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1367 |
| Chain | Residue |
| B | CYS318 |
| B | CYS321 |
| B | HIS341 |
| B | CYS344 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1368 |
| Chain | Residue |
| B | CYS333 |
| B | CYS336 |
| B | CYS360 |
| B | CYS363 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1369 |
| Chain | Residue |
| A | HIS304 |
| B | HIS319 |
| B | GLU362 |
| B | CL1370 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 1370 |
| Chain | Residue |
| A | LYS303 |
| A | HIS304 |
| B | HIS319 |
| B | GLU362 |
| B | ZN1369 |
| B | HOH2006 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 1371 |
| Chain | Residue |
| A | ZN1368 |
| B | HIS304 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TRS B 1372 |
| Chain | Residue |
| A | ASP326 |
| A | HOH2015 |
| A | HOH2016 |
| B | CYS344 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TRS A 1369 |
| Chain | Residue |
| A | CYS344 |
| A | HOH2028 |
| A | HOH2029 |
| A | HOH2044 |
| B | ASP326 |
Functional Information from PROSITE/UniProt
| site_id | PS01359 |
| Number of Residues | 62 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CkhCkddvnrlcrvcachlcggrqdpdkq....................LmCde..Cdma.FHiyCldpplssvpsede................................WyCpeC |
| Chain | Residue | Details |
| A | CYS302-CYS363 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Region: {"description":"Histone H3R2me0 binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Histone H3K4me0 binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Histone H3R2me0 binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
