Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3ZRC

pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001222	molecular_function	transcription corepressor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0016567	biological_process	protein ubiquitination
A	0030891	cellular_component	VCB complex
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0065003	biological_process	protein-containing complex assembly
A	0070449	cellular_component	elongin complex
A	0140958	biological_process	target-directed miRNA degradation
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0001222	molecular_function	transcription corepressor binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0016567	biological_process	protein ubiquitination
D	0030891	cellular_component	VCB complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0065003	biological_process	protein-containing complex assembly
D	0070449	cellular_component	elongin complex
D	0140958	biological_process	target-directed miRNA degradation
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0001222	molecular_function	transcription corepressor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0016567	biological_process	protein ubiquitination
G	0030891	cellular_component	VCB complex
G	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
G	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0065003	biological_process	protein-containing complex assembly
G	0070449	cellular_component	elongin complex
G	0140958	biological_process	target-directed miRNA degradation
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0001222	molecular_function	transcription corepressor binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005829	cellular_component	cytosol
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0016567	biological_process	protein ubiquitination
J	0030891	cellular_component	VCB complex
J	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
J	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0065003	biological_process	protein-containing complex assembly
J	0070449	cellular_component	elongin complex
J	0140958	biological_process	target-directed miRNA degradation
K	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE L8B C 1205

Chain	Residue
C	TRP88
C	HIS115
C	TRP117
C	PHE91
C	TYR98
C	PRO99
C	ARG107
C	ILE109
C	HIS110
C	SER111
C	TYR112

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE L8B F 1205

Chain	Residue
F	TRP88
F	TYR98
F	PRO99
F	LEU101
F	ILE109
F	HIS110
F	SER111
F	TYR112
F	HIS115
F	TRP117

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE L8B I 1207

Chain	Residue
I	ASN67
I	TRP88
I	PHE91
I	TYR98
I	PRO99
I	ARG107
I	ILE109
I	HIS110
I	SER111
I	TYR112
I	HIS115
I	TRP117

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE L8B L 1205

Chain	Residue
L	PRO86
L	TRP88
L	PHE91
L	TYR98
L	PRO99
L	ARG107
L	ILE109
L	HIS110
L	SER111
L	TYR112
L	HIS115
L	TRP117
L	HOH2001

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000269\|Ref.6, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	MET1
D	MET1
G	MET1
J	MET1

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P62869

Chain	Residue	Details
A	THR84
D	THR84
G	THR84
J	THR84

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P62869

Chain	Residue	Details
A	SER108
A	SER111
D	SER108
D	SER111
G	SER108
G	SER111
J	SER108
J	SER111

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)