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3ZR0

Crystal structure of human MTH1 in complex with 8-oxo-dGMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0006281biological_processDNA repair
A0006979biological_processresponse to oxidative stress
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008584biological_processmale gonad development
A0008828molecular_functiondATP diphosphatase activity
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0031965cellular_componentnuclear membrane
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0006281biological_processDNA repair
B0006979biological_processresponse to oxidative stress
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008584biological_processmale gonad development
B0008828molecular_functiondATP diphosphatase activity
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0031965cellular_componentnuclear membrane
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE 8OG A 1157
ChainResidue
ATHR8
ATRP117
AASP119
AASP120
ATRP123
AHOH2019
AHOH2024
AHOH2033
AHOH2034
AHOH2035
AHOH2036
ALEU9
AHOH2134
ALYS23
APHE27
AASN33
AGLY36
AGLY37
APHE72
AMET81

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1158
ChainResidue
AHIS65
ALYS66
AHOH2047
AHOH2068

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1159
ChainResidue
AALA63
AHIS65
ATHR88
AASP89
ASER90
AHOH2067

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 8OG B 1157
ChainResidue
BTHR8
BLEU9
BLYS23
BPHE27
BASN33
BGLY36
BGLY37
BPHE72
BMET81
BTRP117
BASP119
BASP120
BTRP123
BHOH2012
BHOH2017
BHOH2018
BHOH2019

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1158
ChainResidue
BARG151
BVAL153
BASP154
BTHR155

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 1159
ChainResidue
AHOH2128
BHIS134
BARG151

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B 1160
ChainResidue
BHIS65
BLYS66

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG
ChainResidueDetails
AGLY37-GLY58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:30304478, ECO:0007744|PDB:5OTM
ChainResidueDetails
ATHR8
ALYS23
AASN33
ATRP117
BTHR8
BLYS23
BASN33
BTRP117

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:26999531, ECO:0007744|PDB:5FSK
ChainResidueDetails
APHE27
BPHE27

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:26999531, ECO:0000269|PubMed:28035004, ECO:0007744|PDB:5FSI, ECO:0007744|PDB:5GHI, ECO:0007744|PDB:5GHM
ChainResidueDetails
APHE35
BPHE35

site_idSWS_FT_FI4
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3
ChainResidueDetails
AGLY36
BGLU100
AGLU52
AGLU55
AGLU56
AGLU100
BGLY36
BGLU52
BGLU55
BGLU56

225681

PDB entries from 2024-10-02

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