3ZOO

Structure of the Y46F mutant of human cytochrome c

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0006915	biological_process	apoptotic process
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0097190	biological_process	apoptotic signaling pathway
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0097194	biological_process	execution phase of apoptosis
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0006915	biological_process	apoptotic process
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0022904	biological_process	respiratory electron transport chain
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	0097190	biological_process	apoptotic signaling pathway
B	0097193	biological_process	intrinsic apoptotic signaling pathway
B	0097194	biological_process	execution phase of apoptosis
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0006915	biological_process	apoptotic process
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0097190	biological_process	apoptotic signaling pathway
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097194	biological_process	execution phase of apoptosis
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0006915	biological_process	apoptotic process
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0022904	biological_process	respiratory electron transport chain
D	0045333	biological_process	cellular respiration
D	0046872	molecular_function	metal ion binding
D	0097190	biological_process	apoptotic signaling pathway
D	0097193	biological_process	intrinsic apoptotic signaling pathway
D	0097194	biological_process	execution phase of apoptosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEC A 105

Chain	Residue
A	LYS13
A	THR49
A	ASN52
A	TRP59
A	TYR67
A	LEU68
A	THR78
A	LYS79
A	MET80
A	PHE82
A	HOH2070
A	CYS14
B	LYS55
A	CYS17
A	HIS18
A	THR28
A	PRO30
A	THR40
A	GLY41
A	TYR48

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEC B 105

Chain	Residue
B	LYS13
B	CYS14
B	CYS17
B	HIS18
B	THR28
B	GLY29
B	PRO30
B	THR40
B	GLY41
B	TYR48
B	THR49
B	ASN52
B	TRP59
B	TYR67
B	THR78
B	LYS79
B	MET80
B	PHE82
B	HOH2030
B	HOH2034

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC C 105

Chain	Residue
C	LYS13
C	CYS14
C	CYS17
C	HIS18
C	THR28
C	PRO30
C	THR40
C	GLY41
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	TYR67
C	LEU68
C	THR78
C	LYS79
C	MET80
C	PHE82
C	HOH2031
C	HOH2035
D	LYS55

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC D 105

Chain	Residue
A	LYS55
D	LYS13
D	CYS14
D	CYS17
D	HIS18
D	THR28
D	PRO30
D	THR40
D	GLY41
D	TYR48
D	THR49
D	ASN52
D	TRP59
D	TYR67
D	THR78
D	LYS79
D	MET80
D	ILE81
D	PHE82
D	ILE85
D	HOH2042

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 1105

Chain	Residue
A	LYS87
A	LYS88
A	HOH2087
A	HOH2126
A	HOH2144
A	HOH2145
D	LYS79

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 1106

Chain	Residue
A	LYS13
B	LYS73

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"description":"covalent","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23150584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23150584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"PubMed","id":"13933734","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62894","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---