3ZNV

Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990108	biological_process	protein linear deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1347

Chain	Residue
A	HIS276
A	GLN279
A	GLY284
A	GLY285
A	GLU287
A	GLU290

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1348

Chain	Residue
A	GLY270
A	GLN271
A	ARG274
A	GOL1350
A	TRP167
A	ASP268
A	PRO269

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1349

Chain	Residue
A	GLU95
A	TRP96
A	ARG97
A	LYS116
A	GLN303
A	ARG345
A	HOH2036
A	HOH2291

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1350

Chain	Residue
A	TYR165
A	TRP167
A	ILE241
A	TYR244
A	ASN245
A	PRO269
A	GOL1348

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 1351

Chain	Residue
A	SER163
A	HOH2012
A	HOH2333

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1352

Chain	Residue
A	LYS94
A	VAL318
A	HOH2315

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24726327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---