3ZNV

Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990108	biological_process	protein linear deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1347

Chain	Residue
A	HIS276
A	GLN279
A	GLY284
A	GLY285
A	GLU287
A	GLU290

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1348

Chain	Residue
A	GLY270
A	GLN271
A	ARG274
A	GOL1350
A	TRP167
A	ASP268
A	PRO269

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1349

Chain	Residue
A	GLU95
A	TRP96
A	ARG97
A	LYS116
A	GLN303
A	ARG345
A	HOH2036
A	HOH2291

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1350

Chain	Residue
A	TYR165
A	TRP167
A	ILE241
A	TYR244
A	ASN245
A	PRO269
A	GOL1348

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 1351

Chain	Residue
A	SER163
A	HOH2012
A	HOH2333

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1352

Chain	Residue
A	LYS94
A	VAL318
A	HOH2315

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL

Chain	Residue	Details
A	ASP126
A	HIS339

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:24726327, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL

Chain	Residue	Details
A	CYS129

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Linear diubiquitin binding => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSK, ECO:0007744|PDB:4KSL

Chain	Residue	Details
A	GLU314

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