3ZKJ

Crystal Structure of Ankyrin Repeat and Socs Box-Containing Protein 9 (Asb9) in Complex with Elonginb and Elonginc

Replaces:  2XAI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035556	biological_process	intracellular signal transduction
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000151	cellular_component	ubiquitin ligase complex
C	0001222	molecular_function	transcription corepressor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0016567	biological_process	protein ubiquitination
C	0030891	cellular_component	VCB complex
C	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0065003	biological_process	protein-containing complex assembly
C	0070449	cellular_component	elongin complex
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	0140958	biological_process	target-directed miRNA degradation
C	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
C	2000104	biological_process	negative regulation of DNA-templated DNA replication
D	0035556	biological_process	intracellular signal transduction
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000151	cellular_component	ubiquitin ligase complex
F	0001222	molecular_function	transcription corepressor binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0016567	biological_process	protein ubiquitination
F	0030891	cellular_component	VCB complex
F	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
F	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0065003	biological_process	protein-containing complex assembly
F	0070449	cellular_component	elongin complex
F	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
F	0140958	biological_process	target-directed miRNA degradation
F	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
F	2000104	biological_process	negative regulation of DNA-templated DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1295

Chain	Residue
A	ASP133
A	LEU134
A	ALA135
A	SER136
A	GLU140
A	ARG143
A	LEU167

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 1296

Chain	Residue
A	GLU75
A	ASN108

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO D 1295

Chain	Residue
D	ALA155

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL F 1107

Chain	Residue
F	LYS28
F	LEU44
F	LEU50
F	LEU51
F	ASP53
F	HOH2002

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 1297

Chain	Residue
A	SER211
A	GLU212
A	GLU213
D	GLY47
D	HIS48
D	GLN49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	58
Details	Repeat: {"description":"ANK 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	58
Details	Repeat: {"description":"ANK 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	58
Details	Repeat: {"description":"ANK 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	58
Details	Repeat: {"description":"ANK 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	58
Details	Repeat: {"description":"ANK 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Essential for binding to CKB","evidences":[{"source":"PubMed","id":"22418839","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	54
Details	Domain: {"description":"SOCS box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00194","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---