3ZKF

Structure of LC8 in complex with Nek9 phosphopeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000776	cellular_component	kinetochore
A	0001673	cellular_component	male germ cell nucleus
A	0004857	molecular_function	enzyme inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007017	biological_process	microtubule-based process
A	0007286	biological_process	spermatid development
A	0008180	cellular_component	COP9 signalosome
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0019899	molecular_function	enzyme binding
A	0021762	biological_process	substantia nigra development
A	0030141	cellular_component	secretory granule
A	0030235	molecular_function	nitric-oxide synthase regulator activity
A	0030286	cellular_component	dynein complex
A	0032388	biological_process	positive regulation of intracellular transport
A	0035721	biological_process	intraciliary retrograde transport
A	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
A	0035861	cellular_component	site of double-strand break
A	0036487	molecular_function	nitric-oxide synthase inhibitor activity
A	0042326	biological_process	negative regulation of phosphorylation
A	0042802	molecular_function	identical protein binding
A	0044458	biological_process	motile cilium assembly
A	0044877	molecular_function	protein-containing complex binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0070821	cellular_component	tertiary granule membrane
A	0072686	cellular_component	mitotic spindle
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0097110	molecular_function	scaffold protein binding
A	0097542	cellular_component	ciliary tip
A	0101003	cellular_component	ficolin-1-rich granule membrane
A	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
A	1904115	cellular_component	axon cytoplasm
C	0000776	cellular_component	kinetochore
C	0001673	cellular_component	male germ cell nucleus
C	0004857	molecular_function	enzyme inhibitor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005874	cellular_component	microtubule
C	0005875	cellular_component	microtubule associated complex
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0007017	biological_process	microtubule-based process
C	0007286	biological_process	spermatid development
C	0008180	cellular_component	COP9 signalosome
C	0015630	cellular_component	microtubule cytoskeleton
C	0016020	cellular_component	membrane
C	0019899	molecular_function	enzyme binding
C	0021762	biological_process	substantia nigra development
C	0030141	cellular_component	secretory granule
C	0030235	molecular_function	nitric-oxide synthase regulator activity
C	0030286	cellular_component	dynein complex
C	0032388	biological_process	positive regulation of intracellular transport
C	0035721	biological_process	intraciliary retrograde transport
C	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
C	0035861	cellular_component	site of double-strand break
C	0036487	molecular_function	nitric-oxide synthase inhibitor activity
C	0042326	biological_process	negative regulation of phosphorylation
C	0042802	molecular_function	identical protein binding
C	0044458	biological_process	motile cilium assembly
C	0044877	molecular_function	protein-containing complex binding
C	0045505	molecular_function	dynein intermediate chain binding
C	0070821	cellular_component	tertiary granule membrane
C	0072686	cellular_component	mitotic spindle
C	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
C	0097110	molecular_function	scaffold protein binding
C	0097542	cellular_component	ciliary tip
C	0101003	cellular_component	ficolin-1-rich granule membrane
C	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
C	1904115	cellular_component	axon cytoplasm
E	0000776	cellular_component	kinetochore
E	0001673	cellular_component	male germ cell nucleus
E	0004857	molecular_function	enzyme inhibitor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0005875	cellular_component	microtubule associated complex
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0007017	biological_process	microtubule-based process
E	0007286	biological_process	spermatid development
E	0008180	cellular_component	COP9 signalosome
E	0015630	cellular_component	microtubule cytoskeleton
E	0016020	cellular_component	membrane
E	0019899	molecular_function	enzyme binding
E	0021762	biological_process	substantia nigra development
E	0030141	cellular_component	secretory granule
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030286	cellular_component	dynein complex
E	0032388	biological_process	positive regulation of intracellular transport
E	0035721	biological_process	intraciliary retrograde transport
E	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
E	0035861	cellular_component	site of double-strand break
E	0036487	molecular_function	nitric-oxide synthase inhibitor activity
E	0042326	biological_process	negative regulation of phosphorylation
E	0042802	molecular_function	identical protein binding
E	0044458	biological_process	motile cilium assembly
E	0044877	molecular_function	protein-containing complex binding
E	0045505	molecular_function	dynein intermediate chain binding
E	0070821	cellular_component	tertiary granule membrane
E	0072686	cellular_component	mitotic spindle
E	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
E	0097110	molecular_function	scaffold protein binding
E	0097542	cellular_component	ciliary tip
E	0101003	cellular_component	ficolin-1-rich granule membrane
E	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
E	1904115	cellular_component	axon cytoplasm
G	0000776	cellular_component	kinetochore
G	0001673	cellular_component	male germ cell nucleus
G	0004857	molecular_function	enzyme inhibitor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005875	cellular_component	microtubule associated complex
G	0005886	cellular_component	plasma membrane
G	0005929	cellular_component	cilium
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0007017	biological_process	microtubule-based process
G	0007286	biological_process	spermatid development
G	0008180	cellular_component	COP9 signalosome
G	0015630	cellular_component	microtubule cytoskeleton
G	0016020	cellular_component	membrane
G	0019899	molecular_function	enzyme binding
G	0021762	biological_process	substantia nigra development
G	0030141	cellular_component	secretory granule
G	0030235	molecular_function	nitric-oxide synthase regulator activity
G	0030286	cellular_component	dynein complex
G	0032388	biological_process	positive regulation of intracellular transport
G	0035721	biological_process	intraciliary retrograde transport
G	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
G	0035861	cellular_component	site of double-strand break
G	0036487	molecular_function	nitric-oxide synthase inhibitor activity
G	0042326	biological_process	negative regulation of phosphorylation
G	0042802	molecular_function	identical protein binding
G	0044458	biological_process	motile cilium assembly
G	0044877	molecular_function	protein-containing complex binding
G	0045505	molecular_function	dynein intermediate chain binding
G	0070821	cellular_component	tertiary granule membrane
G	0072686	cellular_component	mitotic spindle
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	0097110	molecular_function	scaffold protein binding
G	0097542	cellular_component	ciliary tip
G	0101003	cellular_component	ficolin-1-rich granule membrane
G	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
G	1904115	cellular_component	axon cytoplasm
I	0000776	cellular_component	kinetochore
I	0001673	cellular_component	male germ cell nucleus
I	0004857	molecular_function	enzyme inhibitor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0005875	cellular_component	microtubule associated complex
I	0005886	cellular_component	plasma membrane
I	0005929	cellular_component	cilium
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0007017	biological_process	microtubule-based process
I	0007286	biological_process	spermatid development
I	0008180	cellular_component	COP9 signalosome
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0019899	molecular_function	enzyme binding
I	0021762	biological_process	substantia nigra development
I	0030141	cellular_component	secretory granule
I	0030235	molecular_function	nitric-oxide synthase regulator activity
I	0030286	cellular_component	dynein complex
I	0032388	biological_process	positive regulation of intracellular transport
I	0035721	biological_process	intraciliary retrograde transport
I	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
I	0035861	cellular_component	site of double-strand break
I	0036487	molecular_function	nitric-oxide synthase inhibitor activity
I	0042326	biological_process	negative regulation of phosphorylation
I	0042802	molecular_function	identical protein binding
I	0044458	biological_process	motile cilium assembly
I	0044877	molecular_function	protein-containing complex binding
I	0045505	molecular_function	dynein intermediate chain binding
I	0070821	cellular_component	tertiary granule membrane
I	0072686	cellular_component	mitotic spindle
I	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
I	0097110	molecular_function	scaffold protein binding
I	0097542	cellular_component	ciliary tip
I	0101003	cellular_component	ficolin-1-rich granule membrane
I	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
I	1904115	cellular_component	axon cytoplasm
K	0000776	cellular_component	kinetochore
K	0001673	cellular_component	male germ cell nucleus
K	0004857	molecular_function	enzyme inhibitor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005868	cellular_component	cytoplasmic dynein complex
K	0005874	cellular_component	microtubule
K	0005875	cellular_component	microtubule associated complex
K	0005886	cellular_component	plasma membrane
K	0005929	cellular_component	cilium
K	0006915	biological_process	apoptotic process
K	0006974	biological_process	DNA damage response
K	0007017	biological_process	microtubule-based process
K	0007286	biological_process	spermatid development
K	0008180	cellular_component	COP9 signalosome
K	0015630	cellular_component	microtubule cytoskeleton
K	0016020	cellular_component	membrane
K	0019899	molecular_function	enzyme binding
K	0021762	biological_process	substantia nigra development
K	0030141	cellular_component	secretory granule
K	0030235	molecular_function	nitric-oxide synthase regulator activity
K	0030286	cellular_component	dynein complex
K	0032388	biological_process	positive regulation of intracellular transport
K	0035721	biological_process	intraciliary retrograde transport
K	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
K	0035861	cellular_component	site of double-strand break
K	0036487	molecular_function	nitric-oxide synthase inhibitor activity
K	0042326	biological_process	negative regulation of phosphorylation
K	0042802	molecular_function	identical protein binding
K	0044458	biological_process	motile cilium assembly
K	0044877	molecular_function	protein-containing complex binding
K	0045505	molecular_function	dynein intermediate chain binding
K	0070821	cellular_component	tertiary granule membrane
K	0072686	cellular_component	mitotic spindle
K	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
K	0097110	molecular_function	scaffold protein binding
K	0097542	cellular_component	ciliary tip
K	0101003	cellular_component	ficolin-1-rich granule membrane
K	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
K	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
A	HIS55-GLU69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Region: {"description":"Interaction with ESR1","evidences":[{"source":"PubMed","id":"15891768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15193260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30464262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37696958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---