3ZHA

Molecular basis for the action of the collagen-specific chaperone Hsp47 SERPINH1 and its structure-specific client recognition.

Replaces:  4AWR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005518	molecular_function	collagen binding
A	0005581	cellular_component	collagen trimer
A	0005615	cellular_component	extracellular space
A	0005783	cellular_component	endoplasmic reticulum
A	0030199	biological_process	collagen fibril organization
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005518	molecular_function	collagen binding
B	0005581	cellular_component	collagen trimer
B	0005615	cellular_component	extracellular space
B	0005783	cellular_component	endoplasmic reticulum
B	0030199	biological_process	collagen fibril organization
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005518	molecular_function	collagen binding
C	0005581	cellular_component	collagen trimer
C	0005615	cellular_component	extracellular space
C	0005783	cellular_component	endoplasmic reticulum
C	0030199	biological_process	collagen fibril organization
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005518	molecular_function	collagen binding
D	0005581	cellular_component	collagen trimer
D	0005615	cellular_component	extracellular space
D	0005783	cellular_component	endoplasmic reticulum
D	0030199	biological_process	collagen fibril organization
K	0004867	molecular_function	serine-type endopeptidase inhibitor activity
K	0005518	molecular_function	collagen binding
K	0005581	cellular_component	collagen trimer
K	0005615	cellular_component	extracellular space
K	0005783	cellular_component	endoplasmic reticulum
K	0030199	biological_process	collagen fibril organization
L	0004867	molecular_function	serine-type endopeptidase inhibitor activity
L	0005518	molecular_function	collagen binding
L	0005581	cellular_component	collagen trimer
L	0005615	cellular_component	extracellular space
L	0005783	cellular_component	endoplasmic reticulum
L	0030199	biological_process	collagen fibril organization
P	0004867	molecular_function	serine-type endopeptidase inhibitor activity
P	0005518	molecular_function	collagen binding
P	0005581	cellular_component	collagen trimer
P	0005615	cellular_component	extracellular space
P	0005783	cellular_component	endoplasmic reticulum
P	0030199	biological_process	collagen fibril organization
Q	0004867	molecular_function	serine-type endopeptidase inhibitor activity
Q	0005518	molecular_function	collagen binding
Q	0005581	cellular_component	collagen trimer
Q	0005615	cellular_component	extracellular space
Q	0005783	cellular_component	endoplasmic reticulum
Q	0030199	biological_process	collagen fibril organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SIN A 1421

Chain	Residue
A	ALA63
A	GLU65
A	ASN66
A	VAL313
A	THR314
A	HIS315

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SIN C 1418

Chain	Residue
C	ASN66
C	THR314
C	HIS315
C	ALA63
C	VAL64
C	GLU65

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SIN K 1415

Chain	Residue
K	ALA63
K	GLU65
K	ASN66
K	THR314
K	HIS315
K	HOH2002

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SIN P 1416

Chain	Residue
P	ALA63
P	GLU65
P	ASN66
P	THR314
P	HIS315

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SIN Q 1412

Chain	Residue
Q	ALA63
Q	GLU65
Q	ASN66
Q	VAL313
Q	THR314
Q	HIS315
Q	HOH2002

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Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FYADHPFIFlV

Chain	Residue	Details
A	PHE382-VAL392

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