3ZGO

Re-refined structure of the human Sirt2 apoform

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding
B	0017136	molecular_function	histone deacetylase activity, NAD-dependent
B	0051287	molecular_function	NAD binding
B	0070403	molecular_function	NAD+ binding
C	0017136	molecular_function	histone deacetylase activity, NAD-dependent
C	0051287	molecular_function	NAD binding
C	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	CYS195
A	CYS200
A	CYS221
A	CYS224

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 400

Chain	Residue
B	CYS195
B	CYS200
B	CYS221
B	CYS224

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 400

Chain	Residue
C	CYS200
C	CYS221
C	CYS224
C	CYS195

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE P6G A 1357

Chain	Residue
A	ARG153
A	ILE175
A	GLY177
A	GLU179
A	ARG347
A	GLU348
A	HOH2180
A	HOH2347
B	GLY32
B	ASP37
B	PHE40
B	HOH2007

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE B 1357

Chain	Residue
B	VAL233
B	PHE234
B	PHE235

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE A 1358

Chain	Residue
A	PHE235
C	HOH2369

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE C 1357

Chain	Residue
B	HOH2304
C	ARG153
C	ILE175
C	GLY177
C	GLU179
C	HOH2165

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE C 1358

Chain	Residue
A	ASP294
C	HIS187
C	PHE234
C	PHE235
C	HOH2267

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1359

Chain	Residue
A	PHE234
A	PHE235

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE C 1359

Chain	Residue
C	LEU62
C	PHE309
C	SER311
C	ALA314

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE C 1360

Chain	Residue
C	ASP60
C	ASP60
C	GLU61
C	ARG69

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EOH B 1358

Chain	Residue
B	ARG77
B	ARG78
B	GLY159
B	LEU160
B	LEU161
B	LEU162

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PGE C 1361

Chain	Residue
C	LYS109
C	TYR110
C	HIS111
C	HIS127
C	GLU211
C	LYS212
C	HOH2232
C	HOH2237
C	HOH2383

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	843
Details	Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	39
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RMG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11427894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23454361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24389023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25704306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RJQ4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---