3ZDA
Structure of E. coli ExoIX in complex with a fragment of the Flap1 DNA oligonucleotide, potassium and magnesium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0008409 | molecular_function | 5'-3' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0017108 | molecular_function | 5'-flap endonuclease activity |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0033567 | biological_process | DNA replication, Okazaki fragment processing |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048256 | molecular_function | flap endonuclease activity |
| A | 0140097 | molecular_function | catalytic activity, acting on DNA |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 1251 |
| Chain | Residue |
| A | LEU171 |
| A | ALA172 |
| A | PRO180 |
| A | VAL182 |
| A | ILE185 |
| A | HOH2194 |
| B | DC2 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1252 |
| Chain | Residue |
| A | HOH2019 |
| A | HOH2077 |
| A | HOH2098 |
| A | HOH2240 |
| A | ASP104 |
| A | HOH2017 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PIV A 1253 |
| Chain | Residue |
| A | GLN35 |
| A | LEU36 |
| A | HIS39 |
| A | ARG141 |
| A | TYR143 |
| A | LYS146 |
| A | HOH2056 |
| A | HOH2061 |
| A | HOH2125 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1254 |
| Chain | Residue |
| A | LEU110 |
| A | LYS113 |
| A | ILE240 |
| A | LEU244 |
| A | HOH2231 |
| A | HOH2241 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 89 |
| Details | Domain: {"description":"5'-3' exonuclease","evidences":[{"source":"HAMAP-Rule","id":"MF_01192","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01192","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01192","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
